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Träfflista för sökning "WFRF:(Rhodes Ryan E.) "

Sökning: WFRF:(Rhodes Ryan E.)

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  • Klionsky, Daniel J., et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - : Landes Bioscience. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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  • Chan, Derwin, et al. (författare)
  • Consistency tendency and the theory of planned behavior : a randomized controlled crossover trial in physical activity
  • 2020
  • Ingår i: Psychology and Health. - Abingdon : Routledge. - 0887-0446 .- 1476-8321. ; 35:6, s. 665-684
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: This study examined the effects of consistency tendency on the predictive power of the theory of planned behavior (TPB) in relation to physical activity behavior.Methods: In this randomized controlled cross-over trial, we recruited 770 undergraduate students from Indonesia who were randomly assigned into two groups. Participants completed physical activity versions of TPB measures at T1 (baseline) and T2 (post 1 week), and the International Physical Activity Questionnaire at T3 (post 1 month). At T1 and T2, the TPB questions were either presented in ensemble-order (i.e., consistency tendency supressed) or alternate-order (i.e., consistency tendency facilitated).Results: The parameter estimates of the model (CFI > .92, TLI > .90, SRMR < .08, RMSEA < .08) aligned with the tenets of TPB. As compared to ensemble-order, a TPB measured in alternate-order yielded stronger cross-sectional relationships, but this pattern did not appear in the prospective relationships in TPB (i.e., intention/perceived behavioral control and behavior).Conclusions: Consistency tendency inflated the factor correlations of cross-sectionally measured TPB variables, but the inflation was not observed in the prospective prediction of behavior. Health psychology questionnaires with items presented in ensemble order may represent a viable means of reducing the confounding effect of consistency tendency. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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  • Bangsbo, Jens, et al. (författare)
  • Copenhagen Consensus statement 2019 : physical activity and ageing
  • 2019
  • Ingår i: British Journal of Sports Medicine. - London : BMJ Publishing Group Ltd. - 0306-3674 .- 1473-0480. ; 53:14, s. 856-858
  • Tidskriftsartikel (refereegranskat)abstract
    • From 19th to 22nd November 2018, 26 researchers representing nine countries and a variety of academic disciplines met in Snekkersten, Denmark, to reach evidence-based consensus about physical activity and older adults. It was recognised that the term ‘older adults’ represents a highly heterogeneous population. It encompasses those that remain highly active and healthy throughout the life-course with a high intrinsic capacity to the very old and frail with low intrinsic capacity. The consensus is drawn from a wide range of research methodologies within epidemiology, medicine, physiology, neuroscience, psychology and sociology, recognising the strength and limitations of each of the methods. Much of the evidence presented in the statements is based on longitudinal associations from observational and randomised controlled intervention studies, as well as quantitative and qualitative social studies in relatively healthy community-dwelling older adults. Nevertheless, we also considered research with frail older adults and those with age-associated neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, and in a few cases molecular and cellular outcome measures from animal studies. The consensus statements distinguish between physical activity and exercise. Physical activity is used as an umbrella term that includes both structured and unstructured forms of leisure, transport, domestic and work-related activities. Physical activity entails body movement that increases energy expenditure relative to rest, and is often characterised in terms of intensity from light, to moderate to vigorous. Exercise is defined as a subset of structured physical activities that are more specifically designed to improve cardiorespiratory fitness, cognitive function, flexibility balance, strength and/or power. This statement presents the consensus on the effects of physical activity on older adults’ fitness, health, cognitive functioning, functional capacity, engagement, motivation, psychological well-being and social inclusion. It also covers the consensus on physical activity implementation strategies. While it is recognised that adverse events can occur during exercise, the risk can be minimised by carefully choosing the type of activity undertaken and by consultation with the individual’s physician when warranted, for example, when the individual is frail, has a number of co-morbidities, or has exercise-related symptoms, such as chest pain, heart arrhythmia or dizziness. The consensus was obtained through an iterative process that began with the presentation of the state-of-the-science in each domain, followed by group and plenary discussions. Ultimately, the participants reached agreement on the 30-item consensus statements.
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  • Rhodes, Ryan E., et al. (författare)
  • Mediators of Physical Activity Behaviour Change Interventions among Adults : A Systematic Review and Meta-Analysis
  • 2021
  • Ingår i: Health Psychology Review. - Abingdon, Oxon : Routledge. - 1743-7199 .- 1743-7202. ; 15:2, s. 272-286
  • Tidskriftsartikel (refereegranskat)abstract
    • An understanding of physical activity through mediators of behaviour change is important to evaluate the efficacy of interventions. The purpose of this review is to update prior reviews with meta-analysis to evaluate the state of physical activity interventions that include proposed mediators of behaviour change. Literature was identified through searching for five key databases. Studies were eligible if they described a published experimental or quasi-experimental trial in English examining the effect of an intervention on physical activity behaviour and mediators in non-clinical adult populations with the necessary statistical information to be included in the meta-analytic structural equation modelling analysis. Fifty-one articles (49 samples) met the eligibility criteria. Small overall effects were identified for mediation paths a (r = .16; 95% CI = .10 to .22), b (r = .21; 95% CI .16 to .27), and c (r = .24; 95% CI .12 to .35), c′ (r = .05 to .19) and ab (r = .02 to .07) that showed similar findings by theory and construct. The effect sizes seen in physical activity interventions are mediated by our current theories, but the effects are very small and no one construct/theory appears to be a critical driver of the mediated effect compared to any other. Innovation and increased fidelity of interventions is needed. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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