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Numrering	Referens	Omslagsbild	Hitta
1.	Holmes, Michael V, et al. (författare) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. 2014 Ingår i: BMJ: British Medical Journal. - : BMJ. - 1756-1833. ; 349:Jul 10, s. 4164-4164 Tidskriftsartikel (refereegranskat)abstract To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.
2.	Qian, Frank, et al. (författare) Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation 2023 Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 82:4, s. 336-349 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial.OBJECTIVES: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosa-pentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF.METHODS: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and sub-groups. Associations were pooled using inverse-variance weighted meta-analysis.RESULTS: Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively.CONCLUSIONS: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Wareham, Nichola... (2)Ta bort avgränsningen; Ärnlöv, Johan, 1970- (1); Tjønneland, Anne (1); Boeing, Heiner (1); Sacerdote, Carlotta (1); Khaw, Kay-Tee (1); visa fler...; Hankey, Graeme J. (1); Maitland-Van der Zee ... (1); Lind, Lars (1); Lannfelt, Lars (1); Melander, Olle (1); LaCroix, Andrea Z. (1); Hardy, Rebecca (1); Kuh, Diana (1); Bayes-Genis, Antoni (1); Davey Smith, George (1); Morrow, David A (1); Sattar, Naveed (1); Marklund, Matti (1); Mozaffarian, Dariush (1); Ricceri, Fulvio (1); Skaaby, Tea (1); Linneberg, Allan (1); Eriksson, Per (1); Ikram, M. Arfan (1); Risérus, Ulf, 1967- (1); Langenberg, Claudia (1); Hamsten, Anders (1); Scott, Robert A (1); Verweij, Niek (1); Rotter, Jerome I. (1); Sundström, Johan (1); Folkersen, Lasse (1); Drogan, Dagmar (1); Bergmann, Manuela M (1); Weikert, Cornelia (1); Onland-Moret, N Char ... (1); Nordestgaard, Børge ... (1); Almeida, Osvaldo P. (1); Voortman, Trudy (1); Leander, Karin (1); Laguzzi, Federica (1); Gigante, Bruna (1); Dominiczak, Anna F. (1); Farrall, Martin (1); Padmanabhan, Sandosh (1); Kooperberg, Charles (1); Ross, Owen A. (1); Hakonarson, Hakon (1); Vicente, Astrid M (1); visa färre...

Lärosäte: Uppsala universitet (2); Karolinska Institutet (2); Lunds universitet (1); Högskolan Dalarna (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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