Amyloid-β associated volume loss occurs only in the presence of phospho-tau.

• The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid-β (Aβ) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p-tau(181p) and CSF Aβ(1-42) . We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF Aβ(1-42) only with elevated CSF p-tau(181p) . Our findings indicate that Aβ-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Aged

Aged

80 and over

Amnesia

cerebrospinal fluid

pathology

Amyloid beta-Peptides

cerebrospinal fluid

Atrophy

Cerebral Cortex

pathology

Female

Humans

Longitudinal Studies

Male

Mild Cognitive Impairment

cerebrospinal fluid

pathology

Peptide Fragments

cerebrospinal fluid

tau Proteins

cerebrospinal fluid

Publication and Content Type

ref (subject category)

art (subject category)