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Deep Remission at 1 Year Prevents Progression of Early Crohn's Disease

Ungaro, Ryan C. (author)
Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, New York, USA,Icahn Sch Med Mt Sinai, Div Gastroenterol, New York, NY 10029 USA.
Yzet, Clara (author)
Amiens University Hospital, Department of Gastroenterology, Amiens, France,Amiens Univ Hosp, Dept Gastroenterol, Amiens, France.
Bossuyt, Peter (author)
Imelda Gastroenterology Clinical Research Center, Department of Gastroenterology, Imelda General Hospital, Bonheiden, Belgium,Imelda Gen Hosp, Dept Gastroenterol, Imelda Gastroenterol Clin Res Ctr, Bonheiden, Belgium.
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Baert, Filip J. (author)
AZ Delta Roeselare, Roeselare, Belgium.
Vanasek, Thomas (author)
Second Department of Internal Medicine, University Hospital Hradec Králové, Hradec Králové, Czech Republic,Univ Hosp Hradec Kralove, Dept Internal Med 2, Hradec Kralove, Czech Republic.
D'Haens, Geert R. (author)
Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands.
Joustra, Vincent Wilhelmus (author)
Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands.
Panaccione, Remo (author)
Inflammatory Bowel Disease Unit, University of Calgary, Calgary, Canada,Univ Calgary, Inflammatory Bowel Dis Unit, Calgary, AB, Canada.
Novacek, Gottfried (author)
Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria,Med Univ Vienna, Div Gastroenterol & Hepatol, Vienna, Austria.
Reinisch, Walter (author)
Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria,Med Univ Vienna, Div Gastroenterol & Hepatol, Vienna, Austria.
Armuzzi, Alessandro (author)
Inflammatory Bowel Disease Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy,Univ Cattolica Sacro Cuore, Inflammatory Bowel Dis Unit, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy.
Golovchenko, Oleksandr (author)
Medical Clinical Investigational Center of Medical Center Health Clinic LLC, Vinnytsia, Ukraine,Hlth Clin LLC, Med Clin Invest Ctr, Med Ctr, Vinnytsia, Ukraine.
Prymak, Olga (author)
Medical Clinical Investigational Center of Medical Center Health Clinic LLC, Vinnytsia, Ukraine,Hlth Clin LLC, Med Clin Invest Ctr, Med Ctr, Vinnytsia, Ukraine.
Goldis, Adrian (author)
Universitatea de Medicina si Farmacie, Timisoara, Romania,Univ Med Si Farmacie, Timisoara, Romania.
Travis, Simon P. (author)
Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.
Hébuterne, Xavier (author)
Gastroenterology and Clinical Nutrition Department, Centre Hospitalier Universitaire of Nice, University of Nice Sophia-Antipolis, Nice, France,Univ Nice Sophia Antipolis, CHU Nice, Gastroenterol & Clin Nutr Dept, Nice, France.
Ferrante, Marc (author)
University Hospitals Leuven, Leuven, Belgium,Univ Hosp Leuven, Leuven, Belgium.
Rogler, Gerhard (author)
Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland,Univ Hosp Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.
Fumery, Mathurin (author)
Amiens University Hospital, Department of Gastroenterology, Amiens, France,Amiens Univ Hosp, Dept Gastroenterol, Amiens, France.
Danese, Silvio (author)
Humanitas University, Istituto Clinico Humanitas, Milan, Italy,Humanitas Univ, Ist Clin Humanitas, Milan, Italy.
Rydzewska, Grazyna (author)
Central Clinical Hospital of Ministry of Interior and Administration in Warsaw, Warsaw, Poland,Minist Interior & Adm Warsaw, Cent Clin Hosp, Warsaw, Poland.
Pariente, Benjamin (author)
Claude Huriez Hospital, Lille University, Lille, France,Lille Univ, Claude Huriez Hosp, Lille, France.
Hertervig, Erik (author)
Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Lund, Sweden.
Stanciu, Carol (author)
Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania,Grigore T Popa Univ Med & Pharm, Iasi, Romania.
Serrero, Melanie (author)
Hepato-Gastroenterology Department, North Hospital, University of Mediterranean, Marseille, France,Univ Mediterranean, North Hosp, Hepatogastroenterol Dept, Marseille, France.
Diculescu, Mircea (author)
University of Medicine and Pharmacy "Carol Davila," Bucharest, Romania,Univ Med & Pharm Carol Davila, Bucharest, Romania.
Peyrin-Biroulet, Laurent (author)
Hépato Gastro-Entérologie, Hôpital de Brabois, Nancy, France,Hop Brabois, Hepato Gastroenterol, Nancy, France.
Laharie, David (author)
Service d'Hépato-gastroentérologie et Oncologie Digestive, Hôpital Haut-Lévêque, Bordeaux, France,Hop Haut Leveque, Serv Hepatogastroenterol & Oncol Digest, Bordeaux, France.
Wright, John P. (author)
Kingsbury Hospital, Cape Town, South Africa,Kingsbury Hosp, Cape Town, South Africa.
Gomollón, Fernando (author)
Hospital Clínico de Zaragoza, IIS Aragón, Zaragoza, Spain,Hosp Clin Zaragoza, IIS Aragon, Zaragoza, Spain.
Gubonina, Irina (author)
Military Medical Academy named after S.M. Kirov, Saint Petersburg, Russian Federation,Mil Med Acad, St Petersburg, Russia.
Schreiber, Stefan (author)
Department of Internal Medicine I, Kiel University, Kiel, Germany,Univ Kiel, Dept Internal Med 1, Kiel, Germany.
Motoya, Satoshi (author)
Inflammatory Bowel Disease Center, Sapporo Kosei General Hospital, Sapporo, Japan,Sapporo Kosei Gen Hosp, Inflammatory Bowel Dis Ctr, Sapporo, Hokkaido, Japan.
Hellström, Per M., 1954- (author)
Uppsala universitet,Gastroenterologi/hepatologi
Halfvarson, Jonas, 1970- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Fac Med & Hlth, Dept Gastroenterol, Orebro, Sweden.
Butler, James W. (author)
AbbVie, Inc, North Chicago, Illinois,AbbVie Inc, N Chicago, IL USA.
Petersson, Joel (author)
AbbVie, Inc, North Chicago, Illinois,AbbVie Inc, N Chicago, IL USA.
Petralia, Francesca (author)
Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York, USA,Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Icahn Inst Data Sci & Genom Technol, New York, NY 10029 USA.
Colombel, Jean-Frederic (author)
Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, New York, USA,Icahn Sch Med Mt Sinai, Div Gastroenterol, New York, NY 10029 USA.
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Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, New York, USA Icahn Sch Med Mt Sinai, Div Gastroenterol, New York, NY 10029 USA (creator_code:org_t)
W. B. Saunders Company, 2020
2020
English.
In: Gastroenterology. - : W. B. Saunders Company. - 0016-5085 .- 1528-0012. ; 159:1, s. 139-147
Related links:
http://www.gastrojou...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND & AIMS: We investigated the effects of inducing deep remission in patients with early Crohn's disease (CD).METHODS: We collected follow-up data from 122 patients (mean age, 31.2 ± 11.3 y) with early, moderate to severe CD (median duration, 0.2 years; interquartile range, 0.1-0.5) who participated in the Effect of Tight Control Management on CD (CALM) study, at 31 sites, representing 50% of the original CALM patient population. Fifty percent of patients (n = 61) were randomly assigned to a tight control strategy (increased therapy based on fecal level of calprotectin, serum level of C-reactive protein, and symptoms), and 50% were assigned to conventional management. We categorized patients as those who were vs were not in deep remission (CD endoscopic index of severity scores below 4, with no deep ulcerations or steroid treatment, for 8 or more weeks) at the end of the follow-up period (median, 3.02 years; range, 0.05-6.26 years). The primary outcome was a composite of major adverse outcomes that indicate CD progression during the follow-up period: new internal fistulas or abscesses, strictures, perianal fistulas or abscesses, or hospitalization or surgery for CD. Kaplan-Meier and penalized Cox regression with bootstrapping were used to compare composite rates between patients who achieved or did not achieve remission at the end of the follow-up period.RESULTS: Major adverse outcomes were reported for 34 patients (27.9%) during the follow-up period. Significantly fewer patients in deep remission at the end of the CALM study had major adverse outcomes during the follow-up period (P = .01). When we adjusted for potential confounders, deep remission (adjusted hazard ratio, 0.19; 95% confidence interval, 0.07-0.31) was significantly associated with a lower risk of major adverse outcome.CONCLUSIONS: In an analysis of follow-up data from the CALM study, we associated induction of deep remission in early, moderate to severe CD with decreased risk of disease progression over a median time of 3 years, regardless of tight control or conventional management strategy.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Keyword

Adalimumab
CDEIS
IBD
Inflammatory Bowel Diseases

Publication and Content Type

ref (subject category)
art (subject category)

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