| 1. |
- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 2. |
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| 3. |
- Abeysekara, A. U., et al.
(författare)
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VERITAS and Fermi-LAT Observations of TeV Gamma-Ray Sources Discovered by HAWC in the 2HWC Catalog
- 2018
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Ingår i: Astrophysical Journal. - : Institute of Physics Publishing. - 0004-637X .- 1538-4357. ; 866:1
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Tidskriftsartikel (refereegranskat)abstract
- The High Altitude Water Cherenkov (HAWC) collaboration recently published their 2HWC catalog, listing 39 very high energy (VHE; >100 GeV) gamma-ray sources based on 507 days of observation. Among these, 19 sources are not associated with previously known teraelectronvolt (TeV) gamma-ray sources. We have studied 14 of these sources without known counterparts with VERITAS and Fermi-LAT. VERITAS detected weak gamma-ray emission in the 1 TeV-30 TeV band in the region of DA 495, a pulsar wind nebula coinciding with 2HWC J1953+294, confirming the discovery of the source by HAWC. We did not find any counterpart for the selected 14 new HAWC sources from our analysis of Fermi-LAT data for energies higher than 10 GeV. During the search, we detected gigaelectronvolt (GeV) gamma-ray emission coincident with a known TeV pulsar wind nebula, SNR G54.1+0.3 (VER J1930+188), and a 2HWC source, 2HWC J1930+188. The fluxes for isolated, steady sources in the 2HWC catalog are generally in good agreement with those measured by imaging atmospheric Cherenkov telescopes. However, the VERITAS fluxes for SNR G54.1+0.3, DA 495, and TeV J2032+4130 are lower than those measured by HAWC, and several new HAWC sources are not detected by VERITAS. This is likely due to a change in spectral shape, source extension, or the influence of diffuse emission in the source region.
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| 4. |
- Sungnak, W., et al.
(författare)
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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
- 2020
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Ingår i: Nature Medicine. - : Nature Research. - 1078-8956 .- 1546-170X. ; 26:5, s. 681-687
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Tidskriftsartikel (refereegranskat)abstract
- We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
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| 5. |
- Sikkema, Lisa, et al.
(författare)
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An integrated cell atlas of the lung in health and disease
- 2023
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Ingår i: Nature Medicine. - : Springer Nature. - 1078-8956 .- 1546-170X. ; 29:6, s. 1563-1577
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Tidskriftsartikel (refereegranskat)abstract
- Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations of individual studies and capture the variability present in the population. Here we present the integrated Human Lung Cell Atlas (HLCA), combining 49 datasets of the human respiratory system into a single atlas spanning over 2.4 million cells from 486 individuals. The HLCA presents a consensus cell type re-annotation with matching marker genes, including annotations of rare and previously undescribed cell types. Leveraging the number and diversity of individuals in the HLCA, we identify gene modules that are associated with demographic covariates such as age, sex and body mass index, as well as gene modules changing expression along the proximal-to-distal axis of the bronchial tree. Mapping new data to the HLCA enables rapid data annotation and interpretation. Using the HLCA as a reference for the study of disease, we identify shared cell states across multiple lung diseases, including SPP1 + profibrotic monocyte-derived macrophages in COVID-19, pulmonary fibrosis and lung carcinoma. Overall, the HLCA serves as an example for the development and use of large-scale, cross-dataset organ atlases within the Human Cell Atlas.
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| 6. |
- Ojeda, M., et al.
(författare)
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Synthesis of Rh nano-particles by the microemulsion technology - Particle size effect on the CO+H-2 reaction
- 2004
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Ingår i: Applied Catalysis A. - : Elsevier BV. - 0926-860X .- 1873-3875. ; 274:1-2, s. 33-41
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Tidskriftsartikel (refereegranskat)abstract
- Several alumina-supported rhodium-based catalysts have been prepared using the microemulsion technology. The change of microemulsion properties led to catalysts with different Rh particle size and narrow size distribution while keeping the same metal loading. The metal particle size was determined by XRD and TEM. These catalysts were tested in the CO hydrogenation reaction in order to investigate the influence of the Rh particle size. The catalytic results indicated that turnover frequency (TOF) increased about four times when the Rh particle size increased approximately from
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| 7. |
- Schut, J, et al.
(författare)
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Glass transition temperature prediction of polymers through the mass-per-flexible-bond principle
- 2007
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Ingår i: Polymer. - : Elsevier BV. - 0032-3861 .- 1873-2291. ; 48:20, s. 6115-6124
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Tidskriftsartikel (refereegranskat)abstract
- A semi-empirical method based on the mass-per-flexible-bond (M/f) principle was used to quantitatively explain the large range of glass transition temperatures (T-g) observed in a library of 132 L-tyrosine derived homo, co- and terpolymers containing different functional groups. Polymer class specific behavior was observed in T-g vs. M/f plots, and explained in terms of different densities, steric hindrances and intermolecular interactions of chemically distinct polymers. The method was found to be useful in the prediction of polymer T-g. The predictive accuracy was found to range from 6.4 to 3.7 K, depending on polymer class. This level of accuracy compares favorably with (more complicated) methods used in the literature. The proposed method can also be used for structure prediction of polymers to match a target T-g value, by keeping the thermal behavior of a terpolymer constant while independently choosing its chemistry. Both applications of the method are likely to have broad applications in polymer and (bio)material science.
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| 8. |
- Bombois, Xavier, et al.
(författare)
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Optimal experiment design for hypothesis testing applied to functional magnetic resonance imaging
- 2011
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Ingår i: Proceedings of the 18th IFAC World Congress. ; , s. 9953-9958
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Konferensbidrag (refereegranskat)abstract
- Hypothesis testing is a classical methodology of making decisions using experimental data. In hypothesis testing one seeks to discover evidence that either accepts or rejects a given null hypothesis H0. The alternative hypothesis H1 is the hypothesis that is accepted when H0 is rejected. In hypothesis testing, the probability of deciding H1 when in fact H0 is true is known as the false alarm rate, whereas the probability of deciding H1when in fact H1is true is known as the detection rate (or power) of the test. It is not possible to optimize both rates simultaneously. In this paper, we consider the problem of determining the data to be used for hypothesis testing that maximize the detection rate for a given false alarm rate. We consider in particular a hypothesis test which is relevant in functional magnetic resonance imaging (fMRI).
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| 9. |
- Li, Tian, et al.
(författare)
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Developing fibrillated cellulose as a sustainable technological material
- 2021
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Ingår i: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 590:7844, s. 47-56
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Tidskriftsartikel (refereegranskat)abstract
- Cellulose is the most abundant biopolymer on Earth, found in trees, waste from agricultural crops and other biomass. The fibres that comprise cellulose can be broken down into building blocks, known as fibrillated cellulose, of varying, controllable dimensions that extend to the nanoscale. Fibrillated cellulose is harvested from renewable resources, so its sustainability potential combined with its other functional properties (mechanical, optical, thermal and fluidic, for example) gives this nanomaterial unique technological appeal. Here we explore the use of fibrillated cellulose in the fabrication of materials ranging from composites and macrofibres, to thin films, porous membranes and gels. We discuss research directions for the practical exploitation of these structures and the remaining challenges to overcome before fibrillated cellulose materials can reach their full potential. Finally, we highlight some key issues towards successful manufacturing scale-up of this family of materials. Opportunities for the application of fibrillated cellulose materials-which can be extracted from renewable resources-and broader manufacturing issues of scale-up, sustainability and synergy with the paper-making industry are discussed.
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| 10. |
- Oñate, A., et al.
(författare)
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Production of Nb-doped super duplex stainless steel based on recycled material : A study of the microstructural characterization, corrosion, and mechanical behavior
- 2023
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Ingår i: Materials Chemistry and Physics. - : Elsevier BV. - 0254-0584 .- 1879-3312. ; 308
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Tidskriftsartikel (refereegranskat)abstract
- The corrosion behavior of a new Nb-doped stainless steel (SDSS-Nb) designed by the CALPHAD method, produced using an open atmosphere process based on recycled materials, was investigated to improve the circular economy. Three heat-treatment conditions were evaluated to assess the sensitization effects of the precipitates and inclusions. XRD and SEM-EDS were used for phase identification, and sensitization was analyzed by cyclic polarization and Scanning Kelvin Probe Force Microscopy (SKPFM). The thermodynamic stability predicted by Thermo-Calc agrees with that observed by SEM-EDS. It was observed by cyclic polarization that the corrosion sensitization was mainly provided by the σ phase, which was deduced from the results obtained by SEM-EDS, XRD, and Thermo-Calc simulations. Furthermore, it was obtained that the sensitization due to Cr2N precipitates and nonmetallic inclusions was low, and the mechanical response is comparable to commercial UNS32750 super duplex stainless steel, which allows a good performance in severe environments and an efficient industrial application. Additionally, it has been obtained by SKPFM that the shear potential between the σ phase and the austenite is between 210 mV and 241 mV and that its value depends on the stability and equilibrium reached by the σ phase during thermal cycling.
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