High white matter lesion load is associated with hippocampal atrophy in mild cognitive impairment.

• Mild cognitive impairment (MCI) is a heterogeneous condition suggested as a prodromal state of Alzheimer's disease (AD) and subcortical vascular dementia (SVD). Recent findings suggest that white matter lesions (WML) may be associated with hippocampal atrophy. The objective of the study was to examine hippocampal and WML volumes in MCI patients and to examine if WML were linked to hippocampal atrophy.

Subject headings

HUMANIORA  -- Filosofi, etik och religion -- Filosofi (hsv//swe)

HUMANITIES  -- Philosophy, Ethics and Religion -- Philosophy (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Aged

Alzheimer Disease

pathology

psychology

Apolipoproteins E

genetics

Atrophy

Brain

pathology

Cognition Disorders

pathology

psychology

Dementia

Vascular

pathology

psychology

Educational Status

Female

Hippocampus

pathology

Humans

Longitudinal Studies

Magnetic Resonance Imaging

Male

Middle Aged

Neuropsychological Tests

Publication and Content Type

ref (subject category)

art (subject category)