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| 2. |
- Cossarizza, A., et al.
(författare)
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
- 2019
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 49:10, s. 1457-1973
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Tidskriftsartikel (refereegranskat)abstract
- These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.
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| 4. |
- Babic, M, et al.
(författare)
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NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
- 2020
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 217:8
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Tidskriftsartikel (refereegranskat)abstract
- NKG2D is a danger sensor expressed on different subsets of innate and adaptive lymphocytes. Despite its established role as a potent activator of the immune system, NKG2D-driven regulation of CD4+ T helper (Th) cell–mediated immunity remains unclear. In this study, we demonstrate that NKG2D modulates Th1 and proinflammatory T-bet+ Th17 cell effector functions in vitro and in vivo. In particular, NKG2D promotes higher production of proinflammatory cytokines by Th1 and T-bet+ Th17 cells and reinforces their transcription of type 1 signature genes, including Tbx21. Conditional deletion of NKG2D in T cells impairs the ability of antigen-specific CD4+ T cells to promote inflammation in vivo during antigen-induced arthritis and experimental autoimmune encephalomyelitis, indicating that NKG2D is an important target for the amelioration of Th1- and Th17-mediated chronic inflammatory diseases.
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| 5. |
- Sarri, G, et al.
(författare)
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The application of laser-driven proton beams to the radiography of intense laser–hohlraum interactions
- 2010
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Ingår i: New Journal of Physics. - : IOP Publishing Ltd. - 1367-2630. ; 12:4, s. 045006-
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Tidskriftsartikel (refereegranskat)abstract
- Plasma expansion following the interaction of an intense laser beam with the inner surface of gold hohlraums, emulating conditions relevant to indirect drive inertial confinement fusion (ICF), has been investigated by a radiographic technique which employs a beam of laser-accelerated protons. This probing technique has made it possible to measure the electric field distribution associated with the plasma front and its propagation throughout the interior of the hohlraum with a temporal and spatial resolution of the order of a few ps and μm, respectively. The data indicate that the expanding plasma slows down approaching the opposite walls, possibly due to the interaction with x-ray heated plasma from the non-irradiated walls. The electric field at the plasma front shows a bipolar structure, suggesting the presence of ion-acoustic soliton-like structures cotraveling with the front. Data obtained using enclosed hohlraums suggest the feasibility of this type of diagnosis in gas-filled hohlraums, as currently employed in ICF experiments.
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| 9. |
- Sarri, Gianluca, et al.
(författare)
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Dynamics of Self-Generated, Large Amplitude Magnetic Fields Following High-Intensity Laser Matter Interaction
- 2012
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 109:20, s. 205002-
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Tidskriftsartikel (refereegranskat)abstract
- The dynamics of magnetic fields with an amplitude of several tens of megagauss, generated at both sides of a solid target irradiated with a high-intensity (∼1019 W/cm2) picosecond laser pulse, has been spatially and temporally resolved using a proton imaging technique. The amplitude of the magnetic fields is sufficiently large to have a constraining effect on the radial expansion of the plasma sheath at the target surfaces. These results, supported by numerical simulations and simple analytical modeling, may have implications for ion acceleration driven by the plasma sheath at the rear side of the target as well as for the laboratory study of self-collimated high-energy plasma jets.
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