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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
- Enciso-Mora, Victor (author)
- Broderick, Peter (author)
- Ma, Yussanne (author)
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- Jarrett, Ruth F. (author)
- van den Berg, Anke (author)
- Olver, Bianca (author)
- Lloyd, Amy (author)
- Dobbins, Sara E. (author)
- Lightfoot, Tracy (author)
- van Leeuwen, Flora E. (author)
- Foersti, Asta (author)
- Diepstra, Arjan (author)
- Broeks, Annegien (author)
- Vijayakrishnan, Jayaram (author)
- Shield, Lesley (author)
- Lake, Annette (author)
- Montgomery, Dorothy (author)
- Roman, Eve (author)
- Engert, Andreas (author)
- von Strandmann, Elke Pogge (author)
- Reiners, Katrin S. (author)
- Nolte, Ilja M. (author)
- Adami, Hans-Olov (author)
- Russell, Nicola S. (author)
- Hamilton-Dutoit, Stephen (author)
- de Bruin, Marieke (author)
- Ryder, Lars P. (author)
- Sorensen, Karina Meden (author)
- Chang, Ellen T. (author)
- Taylor, Malcolm (author)
- Cooke, Rosie (author)
- Hofstra, Robert (author)
- Westers, Helga (author)
- van Wezel, Tom (author)
- van Eijk, Ronald (author)
- Ashworth, Alan (author)
- Rostgaard, Klaus (author)
- Melbye, Mads (author)
- Swerdlow, Anthony J. (author)
- Houlston, Richard S. (author)
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- (creator_code:org_t)
- 2010-10-31
- 2010
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1126-1130
- Journal article (peer-reviewed)
Abstract
Subject headings
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- To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10−8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10−13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10−8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10−50). These data provide new insight into the pathogenesis of cHL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Nature Genetics
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- Uppsala University
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- Karolinska Institutet
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