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- Fazl Mashhadi, Azadeh, 1980, et al.
(författare)
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The Volvo Robust Engineering System: how to make robust design work in an industrial context
- 2016
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Ingår i: Total Quality Management and Business Excellence. - : Informa UK Limited. - 1478-3371 .- 1478-3363. ; 27:5-6, s. 1-19
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Tidskriftsartikel (refereegranskat)abstract
- The Volvo Robust Engineering System (VRES) is an adaptation of the robust design concept in an industrial context. It consists of five different principles as a basic value system, and eight practices that contribute to the implementation of system, parameter and tolerance design. VRES was developed through a learning alliancebetween Volvo and Chalmers University of Technology. This paper presents VRES and discusses it in relation to the literature-based robust design methodology, which has been a major inspiration for VRES development. VRES has expanded and validated the concepts previously developed in the literature by adding the elements needed for practical application.
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| 2. |
- Kathiresan, S., et al.
(författare)
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Polymorphisms associated with cholesterol and risk of cardiovascular events
- 2008
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 358:12, s. 1240-1249
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Tidskriftsartikel (refereegranskat)abstract
- Background: Common single-nucleotide polymorphisms (SNPs) that are associated with blood low-density lipoprotein (LDL) or high-density lipoprotein (HDL) cholesterol modestly affect lipid levels. We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease. Methods: We studied SNPs at nine loci in 5414 subjects from the cardiovascular cohort of the Malmo Diet and Cancer Study. We first validated the association between SNPs and either LDL or HDL cholesterol and subsequently created a genotype score on the basis of the number of unfavorable alleles. We used Cox proportional-hazards models to determine the time to the first cardiovascular event in relation to the genotype score. Results: All nine SNPs showed replication of an association with levels of either LDL or HDL cholesterol. With increasing genotype scores, the level of LDL cholesterol increased from 152 mg to 171 mg per deciliter (3.9 to 4.4 mmol per liter), whereas HDL cholesterol decreased from 60 mg to 51 mg per deciliter (1.6 to 1.3 mmol per liter). During follow-up (median, 10.6 years), 238 subjects had a first cardiovascular event. The genotype score was associated with incident cardiovascular disease in models adjusted for covariates including baseline lipid levels (P<0.001). The use of the genotype score did not improve the clinical risk prediction, as assessed by the C statistic. However, there was a significant improvement in risk classification with the use of models that included the genotype score, as compared with those that did not include the genotype score. Conclusions: A genotype score of nine validated SNPs that are associated with modulation in levels of LDL or HDL cholesterol was an independent risk factor for incident cardiovascular disease. The score did not improve risk discrimination but did modestly improve clinical risk reclassification for individual subjects beyond standard clinical factors.
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