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The risk of amenorr...
The risk of amenorrhoea after adjuvant chemotherapy for early stage breast cancer is related to inter-individual variations in chemotherapy-induced leukocyte nadir in young patients : Data from the randomised SBG 2000-1 study
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Rosendahl, Mikkel (author)
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Ahlgren, Johan (author)
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Andersen, Jorn (author)
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- Bergh, Jonas (author)
- Karolinska Institutet
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- Blomquist, Carl (author)
- Uppsala universitet,Enheten för onkologi
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Lidbrink, Elisabet (author)
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- Lindman, Henrik (author)
- Uppsala universitet,Enheten för onkologi
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Mouridsen, Henning (author)
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Bjerre, Karsten (author)
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Andersson, Michael (author)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 45:18, s. 3198-3204
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Study aim: Amenorrhoea is a common side-effect to chemotherapy of premenopausal women. We examine the association between chemotherapy-induced leucopaenia and the development of amenorrhoea in premenopausal women with breast cancer. Materials and methods: in a multi-centre, randomised, controlled study, 1016 premenopausal women received seven series of FEC (F: fluorouracil, E: epirubicin and C: Cyclophosphamide) for early stage breast cancer. In the first series, all patients received standard dose (F: 600 mg/m(2), E: 60 mg/m(2) and C: 600 mg/m(2)). Patients with leukocyte nadir 1.0-1.9 x 10(9)/l continued with standard dose for the remaining six series (STANDARD(REGISTERED), n = 279). Patients with leukocyte nadir >= 2 x 10(9)/l were randomised to standard (STANDARD(RANDOMISED), n = 373) or increased (TAILORED, n = 364) dose of E and C. After each series, leukocyte nadir was evaluated. Absent bleeding after the 5th-7th series of FEC was interpreted as amenorrhoea. Results: The risk of amenorrhoea increased with age. In age-stratified analysis of the STANDARD groups (equal dose, different initial leukocyte nadir) low leukocyte nadir was associated with amenorrhoea for patients in the age-group 25-39 years (P = 0.010). In age-stratified analysis in the randomised groups (different doses, same initial leukocyte nadir) a dose related increased risk of amenorrhoea was found for age-groups 25-39 (RR: 1.15, 95% confidence interval (CI): 1.06-1.24) and 40 44 years (RR:1.21, 95% CI: 1.001-1.47). Conclusion: Age is the most important risk factor of amenorrhoea after FEC chemotherapy. However, for younger patients, lower leukocyte nadir in response to STANDARD FEC treatment or increased doses of C and E were associated with increased risk of amenorrhoea. (C) 2009 Elsevier Ltd. All rights reserved.
Keyword
- Breast cancer
- Amenorrhoea
- Ovarian failure
- Menopause
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rosendahl, Mikke ...
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Ahlgren, Johan
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Andersen, Jorn
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Bergh, Jonas
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Blomquist, Carl
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Lidbrink, Elisab ...
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show more...
-
Lindman, Henrik
-
Mouridsen, Henni ...
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Bjerre, Karsten
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Andersson, Micha ...
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show less...
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University
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Karolinska Institutet