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PNPLA3 I148M (rs738...
PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis
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- Burza, Maria Antonella, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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Molinaro, A. (författare)
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Attilia, M. L. (författare)
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visa fler...
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Rotondo, C. (författare)
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Attilia, F. (författare)
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Ceccanti, M. (författare)
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Ferri, F. (författare)
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Maldarelli, F. (författare)
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Maffongelli, A. (författare)
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De Santis, A. (författare)
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Attili, A. F. (författare)
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- Romeo, Stefano, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin,Wallenberg Laboratory,Institute of Medicine
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Corradini, S. G. (författare)
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(creator_code:org_t)
- 2013-09-19
- 2014
- Engelska.
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Ingår i: Liver International. - : Wiley. - 1478-3223 .- 1478-3231. ; 34:4, s. 514-520
- Relaterad länk:
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https://onlinelibrar...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background & Aims Environmental and genetic factors contribute to alcoholic cirrhosis onset. In particular, age at exposure to liver stressors has been shown to be important in progression to fibrosis in hepatitis C individuals. However, no definite data on the role of age at onset of at-risk alcohol consumption are available. Moreover, patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M (rs738409) variant has been associated with alcoholic cirrhosis, but only in cross-sectional studies. The aim of this study was to investigate the role of age at onset of at-risk alcohol consumption and PNPLA3 I148M variant on alcoholic cirrhosis incidence. A total of 384 at-risk alcohol drinkers were retrospectively examined. The association among age at onset of at-risk alcohol consumption, PNPLA3 I148M variant and cirrhosis incidence was tested. A higher incidence of alcoholic cirrhosis was observed in individuals with an older (>= 24years) compared with a younger (<24) age at onset of at-risk alcohol consumption (P-value<0.001). Moreover, PNPLA3 148M allele carriers showed an increased incidence of cirrhosis (P-value<0.001). Both age at onset of at-risk alcohol consumption and PNPLA3148M allele were independent risk factors for developing cirrhosis (H.R. (95% C.I.): 2.76 (2.18-3.50), P-value<0.001; 1.53(1.07-2.19), P-value=0.021 respectively). The 148M allele was associated with a two-fold increased risk of cirrhosis in individuals with a younger compared with an older age at onset of at-risk alcohol consumption (H.R. (95% C.I.): 3.03(1.53-6.00) vs. 1.61(1.09-2.38). Age at onset of at-risk alcohol consumption and PNPLA3 I148M genetic variant are independently associated with alcoholic cirrhosis incidence.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- alcoholic liver disease
- Age at onset
- incidence
- patatin-like phospholipase domain-containing protein
- fatty liver-disease
- chronic hepatitis-c
- hepatocellular-carcinoma
- fibrosis progression
- histological severity
- polymorphism
- damage
- indexes
- transplantation
- susceptibility
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Burza, Maria Ant ...
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Molinaro, A.
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Attilia, M. L.
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Rotondo, C.
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Attilia, F.
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Ceccanti, M.
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visa fler...
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Ferri, F.
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Maldarelli, F.
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Maffongelli, A.
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De Santis, A.
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Attili, A. F.
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Romeo, Stefano, ...
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Corradini, S. G.
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visa färre...
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och Klinisk medicin
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och Gastroenterologi
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Göteborgs universitet