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Inhibition of the tissue factor factor VIIa complex - Lead optimisation using combinatorial chemistry
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- Roussel, P (author)
- Uppsala universitet
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- Bradley, M (author)
- Uppsala universitet
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- Kane, P (author)
- Uppsala universitet
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- (creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 1999
- English 6219-6230 s.
- In: TETRAHEDRON. - : PERGAMON-ELSEVIER SCIENCE LTD. ; 55:19
- Other publication (other academic/artistic)
Abstract
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- Following a high throughput screen (HTS) for the inhibition of the tissue factor/factor VIIa complex and the identification of a number of original hits a lead optimisation programme was initiated to improve their potency. This necessitated the developme
Keyword
- amidines; combinatorial; solid phase; library; SOLID-PHASE SYNTHESIS; BLOOD-COAGULATION; TRYPANOTHIONE REDUCTASE; MITSUNOBU REACTION; DERIVATIVES; ACTIVATION; CLEAVAGE
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- ovr (subject category)
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- Roussel, P
- Bradley, M
- Kane, P
- Bailey, C
- Arnold, R
- Cross, A
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- TETRAHEDRON
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- Uppsala University
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