| 1. |
- Haeggstrom, JZ, et al.
(författare)
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Leukotriene A4 hydrolase
- 2002
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Ingår i: Prostaglandins & other lipid mediators. - : Elsevier BV. - 1098-8823. ; 68-968-69, s. 495-510
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Haeggström, JZ, et al.
(författare)
-
Leukotriene A4 hydrolase
- 2002
-
Ingår i: Prostaglandins & other lipid mediators. - : Elsevier BV. - 1098-8823. ; 68-69, s. 495-510
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
- Pansell, J, et al.
(författare)
-
Optic nerve sheath diameter is associated with outcome in severe Covid-19
- 2022
-
Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1, s. 17255-
-
Tidskriftsartikel (refereegranskat)abstract
- Neurological symptoms are common in Covid-19 and cerebral edema has been shown post-mortem. The mechanism behind this is unclear. Elevated intracranial pressure (ICP) has not been extensively studied in Covid-19. ICP can be estimated noninvasively with measurements of the optic nerve sheath diameter (ONSD). We performed a cohort study with ONSD ultrasound measurements in severe cases of Covid-19 at an intensive care unit (ICU). We measured ONSD with ultrasound in adults with severe Covid-19 in the ICU at Karolinska University Hospital in Sweden. Patients were classified as either having normal or elevated ONSD. We compared ICU length of stay (ICU-LOS) and 90 day mortality between the groups. 54 patients were included. 11 of these (20.4%) had elevated ONSD. Patients with elevated ONSD had 12 days longer ICU-LOS (95% CI 2 to 23 p = 0.03) and a risk ratio of 2.3 for ICU-LOS ≥ 30 days. There were no significant differences in baseline data or 90 day mortality between the groups. Elevated ONSD is common in severe Covid-19 and is associated with adverse outcome. This may be caused by elevated ICP. This is a clinically important finding that needs to be considered when deciding upon various treatment strategies.
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| 4. |
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