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Chemoendocrine comp...
Chemoendocrine compared with endocrine adjuvant therapies for node-negative breast cancer: predictive value of centrally reviewed expression of estrogen and progesterone receptors--International Breast Cancer Study Group.
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Viale, Giuseppe (author)
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Regan, Meredith M (author)
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Maiorano, Eugenio (author)
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Mastropasqua, Mauro G (author)
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Golouh, Rastko (author)
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Perin, Tiziana (author)
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Brown, Robert W (author)
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- Kovács, Anikó, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Pillay, Komala (author)
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Ohlschlegel, Christian (author)
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Braye, Stephen (author)
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Grigolato, Piergiovanni (author)
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Rusca, Tiziana (author)
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Gelber, Richard D (author)
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Castiglione-Gertsch, Monica (author)
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Price, Karen N (author)
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Goldhirsch, Aron (author)
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Gusterson, Barry A (author)
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Coates, Alan S (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 26:9, s. 1404-10
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https://doi.org/10.1...
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Abstract
Subject headings
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- PURPOSE: To centrally assess estrogen receptor (ER) and progesterone receptor (PgR) levels by immunohistochemistry and investigate their predictive value for benefit of chemo-endocrine compared with endocrine adjuvant therapy alone in two randomized clinical trials for node-negative breast cancer. PATIENTS AND METHODS: International Breast Cancer Study Group Trial VIII compared cyclophosphamide, methotrexate, and fluorouracil (CMF) chemotherapy for 6 cycles followed by endocrine therapy with goserelin with either modality alone in pre- and perimenopausal patients. Trial IX compared three cycles of CMF followed by tamoxifen for 5 years versus tamoxifen alone in postmenopausal patients. Central Pathology Office reviewed 883 (83%) of 1,063 patients on Trial VIII and 1,365 (82%) of 1,669 on Trial IX and determined ER and PgR by immunohistochemistry. Disease-free survival (DFS) was compared across the spectrum of expression of each receptor using the Subpopulation Treatment Effect Pattern Plot methodology. RESULTS: Both receptors displayed a bimodal distribution, with substantial proportions showing no staining (receptor absent) and most of the remainder showing a high percentage of stained cells. Chemo-endocrine therapy yielded DFS superior to endocrine therapy alone for patients with receptor-absent tumors, and in some cases also for those with low levels of receptor expression. Among patients with ER-expressing tumors, additional prediction of benefit was suggested in absent or low PgR in Trial VIII but not in Trial IX. CONCLUSION: Low levels of ER and PgR are predictive of the benefit of adding chemotherapy to endocrine therapy. Low PgR may add further prediction among pre- and perimenopausal but not postmenopausal patients whose tumors express ER.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adult
- Aged
- Antineoplastic Agents
- Hormonal
- therapeutic use
- Antineoplastic Combined Chemotherapy Protocols
- administration & dosage
- therapeutic use
- Breast Neoplasms
- chemistry
- drug therapy
- surgery
- Chemotherapy
- Adjuvant
- Cyclophosphamide
- administration & dosage
- Disease-Free Survival
- Female
- Fluorouracil
- administration & dosage
- Goserelin
- administration & dosage
- Humans
- Immunohistochemistry
- Menopause
- Methotrexate
- administration & dosage
- Middle Aged
- Neoplasms
- Hormone-Dependent
- chemistry
- drug therapy
- Predictive Value of Tests
- Receptors
- Estrogen
- analysis
- Receptors
- Progesterone
- analysis
- Tamoxifen
- administration & dosage
- Treatment Outcome
- Tumor Markers
- Biological
- analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Viale, Giuseppe
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Regan, Meredith ...
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Maiorano, Eugeni ...
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Mastropasqua, Ma ...
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Golouh, Rastko
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Perin, Tiziana
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show more...
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Brown, Robert W
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Kovács, Anikó, 1 ...
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Pillay, Komala
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Ohlschlegel, Chr ...
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Braye, Stephen
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Grigolato, Pierg ...
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Rusca, Tiziana
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Gelber, Richard ...
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Castiglione-Gert ...
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Price, Karen N
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Goldhirsch, Aron
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Gusterson, Barry ...
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Coates, Alan S
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of clini ...
- By the university
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University of Gothenburg