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- JUUL, A, et al.
(författare)
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Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation
- 1995
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X. ; 80:8, s. 2534-2542
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Tidskriftsartikel (refereegranskat)
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- Muller, J, et al.
(författare)
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Management of males with 45,X/46,XY gonadal dysgenesis
- 1999
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Ingår i: Hormone research. - : S. Karger AG. - 0301-0163. ; 52:1, s. 11-14
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Tidskriftsartikel (refereegranskat)abstract
- Males with the 45,X/46,XY karyotype and malformations of the external genitalia carry an increased risk of developing germ cell neoplasia of the gonads. We have studied gonadal tissue from 10 individuals, 0.3–17 years of age, with a male phenotype and either hypospadias and/or cryptorchidism. Four patients, 0.3–15 years of age, had carcinoma in situ, 1 boy had Sertoli-cell-only pattern and the remainder prepubertal histology. Gonadoblastoma or invasive carcinoma was not found. On the basis of our current knowledge we propose a strategy for management and follow-up of these boys in order to detect possible premalignant histological changes early and prevent development of a gonadal tumour.
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