| 1. |
- Khan, J, et al.
(författare)
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Expression profiling in cancer using cDNA microarrays
- 1999
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Ingår i: Electrophoresis. - 0173-0835. ; 20:2, s. 223-229
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Forskningsöversikt (refereegranskat)abstract
- Currently there are over 1,000,000 human expressed sequence tag (EST) sequences available on the public database, representing perhaps 50-90% of all human genes. The cDNA microarray technique is a recently developed tool that exploits this wealth of information for the analysis of gene expression. In this method, DNA probes representing cDNA clones are arrayed onto a glass slide and interrogated with fluorescently labeled cDNA targets. The power of the technology is the ability to perform a genome-wide expression profile of thousands of genes in one experiment. In our review we describe the principles of the microarray technology as applied to cancer research, summarize the literature on its use so far, and speculate on the future application of this powerful technique.
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| 2. |
- Troein, Carl, et al.
(författare)
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An introduction to BioArray software environment
- 2006
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Ingår i: Methods in Enzymology. - 0076-6879. ; 411, s. 99-119
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Forskningsöversikt (refereegranskat)abstract
- BioArray Software Environment (BASE) is a web-based software package for storing, searching, and analyzing locally generated microarray data and information surrounding microarray production. The workflow begins in sample management and, optionally, microtiter plate tracking and ends in visualization and analysis of entire experiments. The relative ease with which new analysis plug-ins can be added has given rise to a plethora of third-party tools, and the licensing terms (GNU GPL) encourage local modifications of the software. This introduction to BASE describes the basics of working with the software, both in general and in more detail for the various parts. It also provides some hints about more advanced usage and a section on what is needed to set up your own BASE server. The information is current as of BASE version 1.2.17b, which was released on November 6, 2005.
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