| 1. |
- Brunet-Ratnasingham, Elsa, et al.
(författare)
-
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity
- 2023
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized COVID-19 patients. Integrated analysis using k-means reveal four patient clusters in a discovery cohort: mechanically ventilated critically-ill cases are subdivided into good prognosis and high-fatality clusters (reproduced in a validation cohort), while non-critical survivors are delineated by high and low antibody responses. Only the high-fatality cluster is enriched for transcriptomic signatures associated with COVID-19 severity, and each cluster has distinct RBD-specific antibody elicitation kinetics. Both critical and non-critical clusters with delayed antibody responses exhibit sustained IFN signatures, which negatively correlate with contemporaneous RBD-specific IgG levels and absolute SARS-CoV-2-specific B and CD4+ T cell frequencies. These data suggest that the “Interferon paradox” previously described in murine LCMV models is operative in COVID-19, with excessive IFN signaling delaying development of adaptive virus-specific immunity.
|
|
| 2. |
- Brunet-Ratnasingham, Elsa, et al.
(författare)
-
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
- 2024
-
Ingår i: Nature Communications. - 2041-1723. ; 15:1, s. 4177-
-
Tidskriftsartikel (refereegranskat)abstract
- Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients with COVID-19. Integrated analysis using k-means reveals four patient clusters in a discovery cohort: mechanically ventilated critically-ill cases are subdivided into good prognosis and high-fatality clusters (reproduced in a validation cohort), while non-critical survivors segregate into high and low early antibody responders. Only the high-fatality cluster is enriched for transcriptomic signatures associated with COVID-19 severity, and each cluster has distinct RBD-specific antibody elicitation kinetics. Both critical and non-critical clusters with delayed antibody responses exhibit sustained IFN signatures, which negatively correlate with contemporaneous RBD-specific IgG levels and absolute SARS-CoV-2-specific B and CD4+ T cell frequencies. These data suggest that the "Interferon paradox" previously described in murine LCMV models is operative in COVID-19, with excessive IFN signaling delaying development of adaptive virus-specific immunity.
|
|
| 3. |
|
|
| 4. |
- Gao, Xindi, et al.
(författare)
-
Cryptococcal Hsf3 controls intramitochondrial ROS homeostasis by regulating the respiratory process
- 2022
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
-
Tidskriftsartikel (refereegranskat)abstract
- Mitochondrial quality control prevents accumulation of intramitochondrial-derived reactive oxygen species (mtROS), thereby protecting cells against DNA damage, genome instability, and programmed cell death. However, underlying mechanisms are incompletely understood, particularly in fungal species. Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function in regulating mtROS independent of the unfolded protein response. CnHsf3 acts in nuclei and mitochondria, and nuclear- and mitochondrial-targeting signals are required for its organelle-specific functions. It represses the expression of genes involved in the tricarboxylic acid cycle while promoting expression of genes involved in electron transfer chain. In addition, CnHsf3 responds to multiple intramitochondrial stresses; this response is mediated by oxidation of the cysteine residue on its DNA binding domain, which enhances DNA binding. Our results reveal a function of HSF proteins in regulating mtROS homeostasis that is independent of the unfolded protein response.
|
|
| 5. |
- Gustafsson, Björn, 1948, et al.
(författare)
-
Changes in household income and poverty in urban China
- 2020
-
Ingår i: Research on China’s Income Distribution and Labor Market (Vol.10, Ch.10). - Beijing, P.R. China : China Human Resources & Social Security Publishing Group Co., Ltd. - 9787516743119 ; , s. 203-223
-
Bokkapitel (refereegranskat)
|
|
| 6. |
- Gustafsson, Björn, 1948, et al.
(författare)
-
China's urban poor – Comparing twice poverty between residents and migrants in 2013 and 2018
- 2023
-
Ingår i: China economic review. - 1043-951X. ; 80
-
Tidskriftsartikel (refereegranskat)abstract
- Using data from the China Household Income Project in 2013 and 2018, this paper studies relative poverty among rural hukou holders living in urban China and urban hukou holders. People living in households with an income below a fixed percent of the median per-capita income and wealth below the same fixed percent of the median per-capita wealth among urban residents are deemed as relative poor. Although migrants with rural hukou living in urban China were more prone to twice poverty than urban residents in 2013, this was not generally the case in 2018. A multivariate analysis shows several factors to be related to the probability of being twice relative poor. Even considering these factors, a rural hukou status increased the probability of being twice relative poor in 2013. In contrast, such an excess risk of being twice relative poor was much lesser outspoken in middle and low-ranking cities in 2018. However, rural to urban migrants living in high-ranking cities had a somewhat higher risk of being relative poor than urban residents with the same characteristics in 2018.
|
|
| 7. |
|
|
| 8. |
- Gustafsson, Björn, 1948, et al.
(författare)
-
Comparing the Receipt of Social Assistance in Urban and Rural China and the Role of Ethnicity
- 2022
-
Ingår i: China: an International Journal. - : Project Muse. - 0219-8614. ; 20:3, s. 122-139
-
Tidskriftsartikel (refereegranskat)abstract
- This article compares receipt of dibao social assistance in rural and urban areas of China using household data from seven province-level units. The probability of dibao receipt is positively related to the number of persons in the household who are older, adults who do not work and to the possibility that the head of household is in poor health. Means testing based on household income is more stringent in urban areas while low household wealth is a more important factor of dibao receipt in rural areas. In rural China, membership of the Communist Party of China (CPC) increases the probability of dibao receipt. A larger proportion of ethnic minority households than majority households receive dibao.
|
|
| 9. |
|
|
| 10. |
|
|
