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Träfflista för sökning "WFRF:(Samuelsson Göran 1951 ) ;pers:(Larsson Nils Göran)"

Sökning: WFRF:(Samuelsson Göran 1951 ) > Larsson Nils Göran

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1.
  • Linder, Tomas, et al. (författare)
  • A family of putative transcription termination factors shared amongst metazoans and plants.
  • 2005
  • Ingår i: Current genetics. - : Springer Science and Business Media LLC. - 0172-8083 .- 1432-0983. ; 48:4, s. 265-9
  • Tidskriftsartikel (refereegranskat)abstract
    • The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.
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2.
  • Wanrooij, Sjoerd, et al. (författare)
  • In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.
  • 2012
  • Ingår i: EMBO reports. - : EMBO. - 1469-3178 .- 1469-221X. ; 13:12, s. 1130-7
  • Tidskriftsartikel (refereegranskat)abstract
    • The mechanisms of mitochondrial DNA replication have been hotly debated for a decade. The strand-displacement model states that lagging-strand DNA synthesis is initiated from the origin of light-strand DNA replication (OriL), whereas the strand-coupled model implies that OriL is dispensable. Mammalian mitochondria cannot be transfected and the requirements of OriL in vivo have therefore not been addressed. We here use in vivo saturation mutagenesis to demonstrate that OriL is essential for mtDNA maintenance in the mouse. Biochemical and bioinformatic analyses show that OriL is functionally conserved in vertebrates. Our findings strongly support the strand-displacement model for mtDNA replication.
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