A family of putative transcription termination factors shared amongst metazoans and plants.

• The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.

Keyword

Amino Acid Sequence

Animals

Basic-Leucine Zipper Transcription Factors

chemistry

genetics

Conserved Sequence

DNA-Binding Proteins

chemistry

genetics

Humans

Mammals

Molecular Sequence Data

Phylogeny

Plants

genetics

Sequence Alignment

Publication and Content Type

ref (subject category)

art (subject category)