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- Ahrén, Bo, et al.
(author)
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Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes.
- 2002
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 25:5, s. 869-75
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Journal article (peer-reviewed)abstract
- OBJECTIVE: Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment modality for type 2 diabetes. To circumvent the drawback of the short half-life of GLP-1, inhibitors of the GLP-1-degrading enzyme dipeptidyl peptidase IV (DPP IV) have been examined. Such inhibitors improve glucose tolerance in insulin-resistant rats and mice. In this study, we examined the 4-week effect of 1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-pyrrolidine (NVP DPP728), a selective, orally active inhibitor of DPP IV, in subjects with diet-controlled type 2 diabetes in a placebo-controlled double-blind multicenter study.RESEARCH DESIGN AND METHODS: A total of 93 patients (61 men and 32 women), aged 64 +/- 9 years (means +/- SD) and with BMI 27.3 +/- 2.7 kg/m(2), entered the study. Fasting blood glucose was 8.5 +/- 1.5 mmol/l, and HbA(1c) was 7.4 +/- 0.7%. Before and after treatment with NVP DPP728 at 100 mg x 3 (n = 31) or 150 mg x 5 (n = 32) or placebo (n = 30), subjects underwent a 24-h study with standardized meals (total 2,000 kcal).RESULTS: Compared with placebo, NVP DPP728 at 100 mg t.i.d. reduced fasting glucose by 1.0 mmol/l (mean), prandial glucose excursions by 1.2 mmol/l, and mean 24-h glucose levels by 1.0 mmol/l (all P < 0.001). Similar reductions were seen in the 150-mg b.i.d. treatment group. Mean 24-h insulin was reduced by 26 pmol/l in both groups (P = 0.017 and P = 0.023). Although not an efficacy parameter foreseen in the study protocol, HbA(1c) was reduced to 6.9 +/- 0.7% in the combined active treatment groups (P < 0.001). Laboratory safety and tolerability was good in all groups.CONCLUSIONS: We conclude that inhibition of DPP IV is a feasible approach to the treatment of type 2 diabetes in the early stage of the disease.
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I lärdomens trädgård : festskrift till Louise Vinge
- 1996
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Editorial collection (other academic/artistic)abstract
- I de fem sinnenas trädgård slår Damen an sitt instrument och musiken ger lyftning och förnöjelse åt alla skapande varelser. Det är naturligt att se Louise Vinge som mittfigur i en lärdomens trädgård, ett tankens och diktens gröna rum, där skilda tiders stämmor ständigt på nytt fås att ljuda genom tolkarens och förmedlarens hängivna arbete. Kolleger och elever vill med boken I lärdomens trädgård tacka Louise Vinge för vad hon betytt under sin tid som professor i litteraturvetenskap i Lund. 35 skribenter har tagit sig an ämnen från en del av de fält där Louise Vinge gjort bestående insatser som litteraturforskare. Studierna kan därmed samsas under sex huvudrubriker: Litteraturhistorieskrivning, Romantikens idéer och texter, Regionernas litteratur, Berättandets former, Möten mellan texter och I diktens trädgård. Inom dessa ramar anknyter skribenterna till egna specialiteter, vilket gör att boken också speglar aktuella tendenser i dagens lundensiska litteraturforskning.
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| 7. |
- Littberger, Inger, et al.
(author)
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Den besatte teckentydaren
- 1996
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In: I lärdomens trädgård: Festskrift till Louise Vinge. Litteratur teater film, nya serien 15.. - 9179663923
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Book chapter (other academic/artistic)abstract
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