Sökning: WFRF:(Sarkadi Anna 1974 )
> Rubertsson Christine 1962 >
Ultrasonographic fe...
Ultrasonographic fetal soft markers in a low-risk population : prevalence, association with trisomies and invasive tests
-
- Åhman, Annika, 1956- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Socialpediatrisk forskning/Sarkadi
-
- Axelsson, Ove, 1944- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Centrum för klinisk forskning i Sörmland (CKFD),Obstetrisk forskning/Högberg
-
- Maras, Gordan (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
-
visa fler...
-
- Rubertsson, Christine, 1962- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Internationell sexuell och reproduktiv hälsa/Larsson
-
- Sarkadi, Anna, 1974- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Socialpediatrisk forskning/Sarkadi
-
- Lindgren, Peter (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Höglund
-
visa färre...
-
(creator_code:org_t)
- 2014-02-21
- 2014
- Engelska.
-
Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 93:4, s. 367-373
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- ObjectiveTo investigate the prevalence of soft markers identified at second trimester ultrasound in a low-risk population and the association of these markers with trisomies and invasive testing.DesignProspective observational study.SettingSwedish University Hospital.PopulationAll women with fetuses examined by ultrasound at 15+0–22+0 weeks gestation between July 2008 and March 2011.MethodsCases with soft markers were compared with non-cases with regard to trisomies and invasive testing.Main outcome measuresPrevalence of soft markers, likelihood ratio for trisomies and risk ratio for invasive tests after detection of soft markers.ResultsSecond trimester ultrasound was performed on 10 710 fetuses. Markers were detected in 5.9% of fetuses. 5.1% were isolated, 0.7% were multiple and 0.1% were combined with an anomaly. Presence of markers showed a positive likelihood ratio for Down syndrome, but the association (likelihood ratio = 7.1) was only statistically significant for the combined category of any marker (isolated, multiple or combined with anomaly). The risk ratio for invasive testing after the second trimester ultrasound was 24.0 in pregnancies with isolated soft markers compared with those without markers.ConclusionIn a low-risk population, soft markers were found in 5.9% of fetuses at second trimester ultrasound. The likelihood ratio for Down syndrome was significant only for any marker (isolated, multiple or combined with anomaly). The presence of soft markers increased the incidence of invasive procedures substantially. Soft markers should be noted when information on second trimester ultrasound is formulated, and all units performing fetal ultrasound examinations should have established routines concerning information management when soft markers are identified.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas