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Ofatumumab retreatm...
Ofatumumab retreatment and maintenance in fludarabine-refractory chronic lymphocytic leukaemia patients
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- Osterborg, Anders (författare)
- Karolinska Institutet
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- Wierda, William G. (författare)
- M D Anderson Canc Ctr, Univ Texas, Houston TX, USA; Canc Therapy Res Ctr, San Antonio TX, USA
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- Mayer, Jiri (författare)
- Fac Hosp Brno, Dept Internal Med Haematooncol, University Hospital, Brno, Czech Republic
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- Hess, Georg (författare)
- Johannes Gutenberg Univ, Mainz, Germany
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- Hillmen, Peter (författare)
- Leeds Teaching Hosp, Leeds, England
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- Schetelig, Johannes (författare)
- Univ Klinickum Carl Gustav Carus, Dresden, Germany
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- Schuh, Anna (författare)
- Churchill Hosp, Oxford, England
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- Smolej, Lukas (författare)
- Fac Med Hradec Kralove, Univ Hosp, Hradec Kralove, Czech Republic; Charles Univ Prague, Hradec Kralove, Czech Republic
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- Beck, Christian (författare)
- Haematol Onkolog Inst, Moenchengladbach, Germany
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- Dreyfus, Brigitte (författare)
- Hop Jean Bernanrd, Poitiers, France
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- Hellman, Andrzej (författare)
- Akad Med Gdansku, Gdansk, Poland
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- Kozlowski, Piotr (författare)
- Region Örebro län
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- Pfreundschuh, Michael (författare)
- Univ Saarlandes Kliniken, Homburg, Germany
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- Rizzi, Rita (författare)
- Azienda ospedaliero-universitaria consorziale policlinico, Bari, Italy
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- Spacek, Martin (författare)
- Fak Nemocnice, Prague, Czech Republic.
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- Phillips, Jennifer L. (författare)
- GlaxoSmithKline, Collegeville PA, USA
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Gupta, Ira V. (författare)
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- Williams, Vanessa (författare)
- Glaxo SmithKline, Durham NC, USA
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- Jewell, Roxanne C. (författare)
- Glaxo SmithKline, Durham NC ,USA.
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- Nebot, Noelia (författare)
- Glaxo SmithKline, Durham NC, USA
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- Lisby, Steen (författare)
- Genmab AS, Copenhagen, Denmark
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- Dyer, Martin J. S. (författare)
- Ernest & Helen Scott Haematol Res Inst, Univ Leicester, Leicester, England
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(creator_code:org_t)
- 2015-03-30
- 2015
- Engelska.
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 170:1, s. 40-49
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- There are limited data on retreatment with monoclonal antibodies (mAb) in patients with chronic lymphocytic leukaemia (CLL). In a pivotal study, ofatumumab (human anti-CD20 mAb) monotherapy demonstrated a 47% objective response rate (ORR) in fludarabine refractory CLL patients. From this study, a subset of 29 patients who had at least stable disease and then progressed were retreated with eight weekly ofatumumab infusions (induction treatment period), followed by monthly infusions for up to 2years (maintenance treatment period). The ORR after 8weeks of induction retreatment was 45% and 24% had continued disease control after maintenance at 52weeks. Efficacy and safety of the retreated patients were compared with their initial results in the pivotal study. Response duration was 241months vs. 68months; time to next therapy was 148months vs. 123months; and progression-free survival was 74months vs. 79months (medians). Upon retreatment, 72% had infusion reactions, mostly Grade 1-2. Three patients had fatal infections. In summary, ofatumumab retreatment and maintenance therapy was feasible in patients with heavily pretreated CLL and appeared to result in more durable disease control than initial ofatumumab treatment in this subset of patients who may have a more favourable disease profile.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- ofatumumab
- chronic lymphocytic leukaemia
- anti-CD20 monoclonal antibody
- retreatment
- maintenance
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- art (ämneskategori)
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- Av författaren/redakt...
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Osterborg, Ander ...
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Wierda, William ...
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Mayer, Jiri
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Hess, Georg
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Hillmen, Peter
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Schetelig, Johan ...
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visa fler...
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Schuh, Anna
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Smolej, Lukas
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Beck, Christian
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Dreyfus, Brigitt ...
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Hellman, Andrzej
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Kozlowski, Piotr
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Pfreundschuh, Mi ...
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Rizzi, Rita
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Spacek, Martin
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Phillips, Jennif ...
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Gupta, Ira V.
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Williams, Vaness ...
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Jewell, Roxanne ...
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Nebot, Noelia
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Lisby, Steen
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Dyer, Martin J. ...
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