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Sökning: WFRF:(Schiöth Helgi B.) > Stockholms universitet

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1.
  • Cedernaes, Jonathan, et al. (författare)
  • Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
  • 2018
  • Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 4:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Curtailed sleep promotes weight gain and loss of lean mass in humans, although the underlying molecular mechanisms are poorly understood. We investigated the genomic and physiological impact of acute sleep loss in peripheral tissues by obtaining adipose tissue and skeletal muscle after one night of sleep loss and after one full night of sleep. We find that acute sleep loss alters genome-wide DNA methylation in adipose tissue, and unbiased transcriptome-, protein-, and metabolite-level analyses also reveal highly tissue-specific changes that are partially reflected by altered metabolite levels in blood. We observe transcriptomic signatures of inflammation in both tissues following acute sleep loss, but changes involving the circadian clock are evident only in skeletal muscle, and we uncover molecular signatures suggestive of muscle breakdown that contrast with an anabolic adipose tissue signature. Our findings provide insight into how disruption of sleep and circadian rhythms may promote weight gain and sarcopenia.
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2.
  • Dang, Junhua, et al. (författare)
  • The Beauty of the Zero : Replications and Extensions of the Hidden-Zero Effect in Delay Discounting Tasks
  • 2021
  • Ingår i: Social Psychology and Personality Science. - : SAGE Publications. - 1948-5506 .- 1948-5514. ; 12:4, s. 544-549
  • Tidskriftsartikel (refereegranskat)abstract
    • Unlike the presentation format in a typical delay discounting task (e.g., Would you prefer [A] US$4.3 today OR [B] US$7.5 in 22 days?), Magen et al. inserted a zero to each alternative (e.g., Would you prefer [A] US$4.3 today and US$0 in 22 days OR [B] US$0 today and US$7.5 in 22 days?) and found this manipulation effectively reduced delay discounting (d= .84), which was referred to as the hidden-zero effect. Study 1 was a direct replication of this effect. In Study 2, we tested whether the explicit-zero format could buffer against the detrimental effect of exposure to sexy cues on delay discounting. In Study 3, we explored the mechanism underlying the hidden-zero effect. Taken together, the hidden-zero effect was consistently found across all studies (N= 2,440) and our internal meta-analysis yielded a medium to large effect size (d= .52).
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