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Träfflista för sökning "WFRF:(Schick H.) "

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Numrering	Referens	Omslagsbild	Hitta
1.	Ligthart, S., et al. (författare) Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders 2018 Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 103:5, s. 691-706 Tidskriftsartikel (refereegranskat)
2.	Day, FR, et al. (författare) Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair 2015 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:11, s. 1294- Tidskriftsartikel (refereegranskat)
3.	Day, FR, et al. (författare) Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair EDITORIAL COMMENT 2015 Ingår i: OBSTETRICAL & GYNECOLOGICAL SURVEY. - : Ovid Technologies (Wolters Kluwer Health). - 0029-7828. ; 70:12, s. 758-762 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
4.	Seufferlein, T, et al. (författare) [S3-guideline exocrine pancreatic cancer] 2013 Ingår i: Zeitschrift fur Gastroenterologie. - : Georg Thieme Verlag KG. - 1439-7803 .- 0044-2771. ; 51:12, s. 1395-1440 Tidskriftsartikel (refereegranskat)
5.	Angeli, JPF, et al. (författare) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice 2014 Ingår i: Nature cell biology. - : Springer Science and Business Media LLC. - 1476-4679 .- 1465-7392. ; 16:12, s. 1180-U120 Tidskriftsartikel (refereegranskat)
6.	Kilpeläinen, Tuomas O, et al. (författare) Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 2016 Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7 Tidskriftsartikel (refereegranskat)abstract Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.
7.	Schick-Makaroff, K, et al. (författare) Divergent Perspectives on the Use of the Edmonton Symptom Assessment System (Revised) in Palliative Care 2020 Ingår i: Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association. - 1539-0705. ; 22:1, s. 75-81 Tidskriftsartikel (refereegranskat)
8.	Biederstädt, A., et al. (författare) SUMO pathway inhibition targets an aggressive pancreatic cancer subtype 2020 Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 69, s. 1472-1482 Tidskriftsartikel (refereegranskat)abstract Objective: Pancreatic ductal adenocarcinoma (PDAC) still carries a dismal prognosis with an overall 5-year survival rate of 9%. Conventional combination chemotherapies are a clear advance in the treatment of PDAC; however, subtypes of the disease exist, which exhibit extensive resistance to such therapies. Genomic MYC amplifications represent a distinct subset of PDAC with an aggressive tumour biology. It is clear that hyperactivation of MYC generates dependencies that can be exploited therapeutically. The aim of the study was to find and to target MYC-associated dependencies. Design: We analysed human PDAC gene expression datasets. Results were corroborated by the analysis of the small ubiquitin-like modifier (SUMO) pathway in a large PDAC cohort using immunohistochemistry. A SUMO inhibitor was used and characterised using human and murine two-dimensional, organoid and in vivo models of PDAC. Results: We observed that MYC is connected to the SUMOylation machinery in PDAC. Components of the SUMO pathway characterise a PDAC subtype with a dismal prognosis and we provide evidence that hyperactivation of MYC is connected to an increased sensitivity to pharmacological SUMO inhibition. Conclusion: SUMO inhibitor-based therapies should be further developed for an aggressive PDAC subtype. © 2020 American Medical Association. All rights reserved.
9.	Borghei-Razavi, H, et al. (författare) Anterior petrosal approach: The safety of Kawase triangle as an anatomical landmark for anterior petrosectomy in petroclival meningiomas 2015 Ingår i: Clinical neurology and neurosurgery. - : Elsevier BV. - 1872-6968 .- 0303-8467. ; 139, s. 282-287 Tidskriftsartikel (refereegranskat)
10.	Borghei-Razavi, H, et al. (författare) "Münster correlation" in temporal bone: surgical relevance of an anatomical study 2014 Ingår i: Anatomical science international. - : Springer Science and Business Media LLC. - 1447-073X .- 1447-6959. ; 89:2, s. 112-117 Tidskriftsartikel (refereegranskat)

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Typ av publikation: tidskriftsartikel (24)

Typ av innehåll: refereegranskat (23); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Metspalu, Andres (5); Loos, Ruth J F (5); Melander, Olle (4); Deloukas, Panos (4); Franks, Paul W. (4); Wareham, Nicholas J. (4); visa fler...; Auer, Paul L. (4); Orho-Melander, Marju (4); Scott, Robert A (4); Kathiresan, Sekar (4); Reiner, Alex P. (4); Li, X. (3); Willemsen, G (3); Fereshtehnejad, SM (3); Langenberg, C. (3); Tanaka, T. (3); Raitakari, Olli T (3); Teumer, A (3); Ferrucci, L (3); Gudnason, V (3); Hofman, A (3); Sattar, Naveed (3); McCarthy, Mark I (3); Boerwinkle, E (3); Chasman, Daniel I. (3); Kraft, P (3); Campbell, H (3); Peters, Annette (3); Strauch, Konstantin (3); Samani, Nilesh J. (3); Sijbrandij, M (3); Mahajan, Anubha (3); Peloso, Gina M. (3); Deary, Ian J (3); Hayward, C. (3); Rivadeneira, Fernand ... (3); Mihailov, E (3); Harris, Tamara B (3); Liu, Yongmei (3); Hofman, Albert (3); Uitterlinden, André ... (3); Hayward, Caroline (3); Vuckovic, D (3); Tardif, Jean-Claude (3); Lange, Leslie A. (3); Boerwinkle, Eric (3); Schunkert, Heribert (3); Wilson, James G. (3); Erdmann, Jeanette (3); Meisinger, Christa (3); visa färre...

Lärosäte: Karolinska Institutet (13); Lunds universitet (7); Uppsala universitet (6); Umeå universitet (4); Göteborgs universitet (3); Mittuniversitetet (3); visa fler...; Kungliga Tekniska Högskolan (1); Stockholms universitet (1); visa färre...

Språk: Engelska (24)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (12); Naturvetenskap (2); Lantbruksvetenskap (1); Samhällsvetenskap (1)

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