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Antilymphocyte glob...
Antilymphocyte globulin for matched sibling donor transplantation in patients with myelofibrosis
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- Robin, Marie (författare)
- Hop St Louis, France
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- Chevret, Sylvie (författare)
- Univ Paris 07, France
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- Koster, Linda (författare)
- EBMT Data Off Leiden, Netherlands
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- Wolschke, Christine (författare)
- Univ Hosp Eppendorf, Germany
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- Yakoub-Agha, Ibrahim (författare)
- Univ Lille, France
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- Bourhis, Jean Henri (författare)
- Univ Paris Saclay, France
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- Chevallier, Patrice (författare)
- CHU Nantes, France
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- Cornelissen, Jan J. (författare)
- Erasmus Univ, Netherlands
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- Remenyi, Peter (författare)
- St Istvan and St Laszlo Hosp, Hungary
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- Maertens, Johan (författare)
- Univ Hosp Gasthuisberg, Belgium
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- Poire, Xavier (författare)
- Clin Univ St Luc, Belgium
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- Craddock, Charles (författare)
- Queen Elizabeth Hosp, England
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- Socie, Gerard (författare)
- Hop St Louis, France
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- Itala-Remes, Maija (författare)
- HUCH Comprehens Canc Ctr, Finland
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- Schouten, Harry C. (författare)
- Univ Hosp Maastricht, Netherlands
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- Marchand, Tony (författare)
- CHU Rennes, France
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- Passweg, Jakob (författare)
- Univ Hosp, Switzerland
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- Blaise, Didier (författare)
- Aix Marseille Univ, France
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- Damaj, Gandhi (författare)
- CHU Caen, France
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- Ozkurt, Zubeyde Nur (författare)
- Gazi Univ, Turkey
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- Zuckerman, Tsila (författare)
- Rambam Med Ctr, Israel
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- Cluzeau, Thomas (författare)
- Univ Cote Azur, France
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- Labussiere-Wallet, Helene (författare)
- Ctr Hosp Lyon Sud, France
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- Cammenga, Jörg (författare)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- McLornan, Donal (författare)
- Kings Coll London, England
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- Chalandon, Yves (författare)
- Univ Geneva, Switzerland; Univ Geneva, Switzerland
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- Kroger, Nicolaus (författare)
- EBMT Data Off Leiden, Netherlands
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(creator_code:org_t)
- 2019-01-17
- 2019
- Engelska.
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Ingår i: Haematologica. - : FERRATA STORTI FOUNDATION. - 0390-6078 .- 1592-8721. ; 104:6, s. 1230-1236
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://haematologic...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The use of antihuman T-lymphocyte immunoglobulin in the setting of transplantation from an HLA-matched related donor is still much debated. Acute and chronic graft-versus-host disease are the main causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis. The aim of this study was to evaluate the effect of antihuman T-lymphocyte immunoglobulin in a large cohort of patients with myelofibrosis (n= 287). The cumulative incidences of grade II-IV acute graft-versus-host disease among patients who were or were not given antihuman T-lymphocyte immunoglobulin were 26% and 41%, respectively. The corresponding incidences of chronic graft-versus-host disease were 52% and 55%, respectively. Non-adjusted overall survival, disease-free survival and non-relapse mortality rates were 55% versus 53%, 49% versus 45%, and 32% versus 31%, respectively, among the patients who were or were not given antihuman T-lymphocyte immunoglobulin. An adjusted model confirmed that the risk of acute graft-versus-host disease was lower following antihuman T-lymphocyte immunoglobulin (hazard ratio, 0.54; P= 0.010) while it did not decrease the risk of chronic graft-versus-host disease. The hazard ratios for overall survival and non-relapse mortality were 0.66 and 0.64, with P-values of 0.05 and 0.09, respectively. Antihuman T-lymphocyte immunoglobulin did not influence disease-free survival, graft-versus-host disease, relapse-free survival or relapse risk. In conclusion, in the setting of matched related transplantation in myelofibrosis patients, this study demonstrates that antihuman T-lymphocyte immunoglobulin decreases the risk of acute graft-versushost disease without increasing the risk of relapse.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Robin, Marie
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Chevret, Sylvie
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Koster, Linda
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Wolschke, Christ ...
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Yakoub-Agha, Ibr ...
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Bourhis, Jean He ...
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visa fler...
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Chevallier, Patr ...
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Cornelissen, Jan ...
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Remenyi, Peter
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Maertens, Johan
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Poire, Xavier
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Craddock, Charle ...
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Socie, Gerard
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Itala-Remes, Mai ...
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Schouten, Harry ...
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Marchand, Tony
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Passweg, Jakob
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Blaise, Didier
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Damaj, Gandhi
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Ozkurt, Zubeyde ...
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Zuckerman, Tsila
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Cluzeau, Thomas
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Labussiere-Walle ...
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Cammenga, Jörg
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McLornan, Donal
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Chalandon, Yves
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Kroger, Nicolaus
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