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Search: WFRF:(Schulze TG) > University of Gothenburg > English

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1.	de Jong, S, et al. (author) Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder 2018 In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 1, s. 163- Journal article (peer-reviewed)abstract Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
2.	Lee, PH, et al. (author) Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders 2019 In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 179:7, s. 1469- Journal article (peer-reviewed)
3.	Lee, SH, et al. (author) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs 2013 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:9, s. 984- Journal article (peer-reviewed)
4.	Li, M, et al. (author) Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis 2016 In: Molecular neurobiology. - : Springer Science and Business Media LLC. - 1559-1182 .- 0893-7648. ; 53:10, s. 6608-6619 Journal article (peer-reviewed)
5.	O'Dushlaine, C, et al. (author) Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways 2015 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 18:2, s. 199-209 Journal article (peer-reviewed)
6.	Schubert, KO, et al. (author) Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients 2022 In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 12:1, s. 278- Journal article (other academic/artistic)
7.	Sklar, P, et al. (author) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 2011 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:10, s. 977-U162 Journal article (peer-reviewed)
8.	Smoller, JW, et al. (author) Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 2013 In: Lancet. - 1474-547X. ; 381:9875, s. 1371-9 Journal article (peer-reviewed)abstract Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia.
9.	Stahl, EA, et al. (author) Genome-wide association study identifies 30 loci associated with bipolar disorder 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:5, s. 793- Journal article (peer-reviewed)
10.	Sullivan, PF, et al. (author) A mega-analysis of genome-wide association studies for major depressive disorder 2013 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 18:4, s. 497-511 Journal article (peer-reviewed)

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Result 1-10 of 10

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Type of publication: journal article (10)

Type of content: peer-reviewed (9); other academic/artistic (1)

Author/Editor: Landén, Mikael, 1966 (10); Rietschel, M (10); Schulze, TG (10); Cichon, S (9); Nothen, MM (8); Smoller, JW (8); show more...; Ripke, S (8); Bellivier, F. (8); Etain, B. (8); Jamain, S. (8); Reif, A. (8); Sullivan, PF (7); Breen, G (7); Landen, M (7); Craddock, N (7); Mattheisen, M (7); McMahon, FJ (7); Muller-Myhsok, B (7); Martin, NG (7); Lucae, S (7); Backlund, L (7); Degenhardt, F (7); Bauer, M (7); Schalling, M (7); Herms, S. (7); Leboyer, M. (7); Bergen, SE (7); Perlis, RH (7); Strohmaier, J (7); Frank, J (7); Witt, SH (7); Andreassen, OA (6); Melle, I (6); Mitchell, PB (6); OSBY, U (6); Montgomery, GW (6); Levinson, DF (6); Byrne, EM (6); Wray, NR (6); Lewis, CM (6); Lichtenstein, P. (6); Frisen, L. (6); Daly, MJ (6); Treutlein, J (6); O'Donovan, MC (6); Morken, G (6); Gill, M. (6); Blackwood, DHR (6); Gordon, SD (6); Maier, W (6); show less...

University: University of Gothenburg (10)Undo refine; Karolinska Institutet (10); Umeå University (2)

Language: English (10)Undo refine

Research subject (UKÄ/SCB): Medical and Health Sciences (10)

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