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Adrenocorticotropin...
Adrenocorticotropin-independent Cushing's syndrome in pregnancy related to overexpression of adrenal luteinizing hormone/human chorionic gonadotropin receptors
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- Rask, Eva, 1958- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Örebro University Hospital, Sweden
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- Schvarcz, E. (author)
- Department of Medicine, Örebro University Hospital, Sweden
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- Hellman, Per (author)
- Uppsala universitet,Endokrinkirurgi,Department of Surgery, Institute of Medical Sciences, Uppsala, Sweden
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- Hennings, Joakim (author)
- Uppsala universitet,Endokrinkirurgi,Department of Surgery, Institute of Medical Sciences, Uppsala, Sweden
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- Karlsson, F. A. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Internal Medicine, Division of Research, Uppsala University Hospital, Uppsala, Sweden
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- Rao, C. V. (author)
- Florida International University College of Medicine, Miami, FL, United States
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(creator_code:org_t)
- Editrice kurtis, 2009
- 2009
- English.
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In: Journal of Endocrinological Investigation. - : Editrice kurtis. - 0391-4097 .- 1720-8386. ; 32:4, s. 313-316
- Related links:
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Cushing's syndrome during pregnancy is rare, and rather than being of pituitary origin most patients exhibit ACTH-independent adrenal hypercortisolism. In some cases the syndrome has spontaneously resolved post partum, suggesting the presence of a pregnancy-associated stimulatory factor(s). We describe a case with aberrant adrenal LH/hCG receptors in a large adrenal tumor as a possible explanation for cortisol hypersecretion and tumor growth in Cushing s syndrome during pregnancy. A 27-yr-old woman presented with hypertension and diabetes mellitus in early pregnancy. Investigations revealed hypercortisolemia, suppressed ACTH-levels, and a 6.4- cm right adrenal tumor. The tumor was successfully removed by laparoscopy at 26th week of pregnancy. Hypercortisolism and hypertension resolved post-operatively. The tumor displayed higher LH/hCG receptor mRNA and protein positivity than adjacent normal adrenal tissue as examined by in situ hybridization and immunocytochemistry. High physiological levels of hCG, in conjunction with aberrant adrenal LH/hCG receptor overexpression, may have contributed to the development of Cushing's syndrome in pregnancy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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