| 1. |
- Boustedt, Jonas, et al.
(författare)
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It seemed like a good idea at the time
- 2008
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Ingår i: SIGCSE '08. - New York, NY, USA : ACM. - 9781595937995 ; , s. 528-529
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We often learn of successful pedagogical experiments, but we seldom hear of the the ones that failed. For this special session we solicited submissions from the SIGCSE membership, selected the best from among these, and will have presentations at the session by the selected authors. Our contributions describe pedagogical approaches that seemed to be good ideas but turned out as failures. Contributors will describe their pedagogical experiment, the rationale for the experiment, evidence of failure, and lessons learned.
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| 2. |
- Ingelsson, Erik, et al.
(författare)
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Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
- 2010
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Ingår i: Diabetes. - 0012-1797 .- 1939-327X. ; 59:5, s. 1266-1275
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Konferensbidrag (refereegranskat)abstract
- OBJECTIVE-Recent genome-wide association studies have revealed loci associated with glucose and insulin-related traits. We aimed to characterize 19 such loci using detailed measures of insulin processing, secretion, and sensitivity to help elucidate their role in regulation of glucose control, insulin secretion and/or action. RESEARCH DESIGN AND METHODS-We investigated associations of loci identified by the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) with circulating proinsulin, measures of insulin secretion and sensitivity from oral glucose tolerance tests (OGTTs), euglycemic clamps, insulin suppression tests, or frequently sampled intravenous glucose tolerance tests in nondiabetic humans (n = 29,084). RESULTS-The glucose-raising allele in MADD was associated with abnormal insulin processing (a dramatic effect on higher proinsulin levels, but no association with insulinogenic index) at extremely persuasive levels of statistical significance (P = 2.1 x 10(-71)). Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B. Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity). Two loci previously associated with fasting insulin (GCKR and IGF1) were associated with OGTT-derived insulin sensitivity indices in a consistent direction. CONCLUSIONS-Genetic loci identified through their effect on hyperglycemia and/or hyperinsulinemia demonstrate considerable heterogeneity in associations with measures of insulin processing, secretion, and sensitivity. Our findings emphasize the importance of detailed physiological characterization of such loci for improved understanding of pathways associated with alterations in glucose homeostasis and eventually type 2 diabetes. Diabetes 59:1266-1275, 2010
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| 3. |
- Mazurkewich, Scott, 1982, et al.
(författare)
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Mechanism of the glucuronoyl esterase OtCE15A: an alpha/beta hydrolase involved with biomass conversion
- 2022
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Glucuronoyl esterases are α/β serine hydrolases from Carbohydrate Esterase family 15 (CE15) which cleave an ester linkage that connects lignin to glucuronyl xylan, an important linkage contributing to biomass recalcitrance. Presented here is our recent work on probing the enzyme-substrate interactions of a model glucuronoyl esterase, Ot CE15A from the soil bacterium Opitutus terrae , through combined structural, kinetic, and QM/MM investigations. These new investigations greatly add to the knowledge of enzyme-substrate interactions in CE15 and enhances our understanding as to how these enzymes may act in natural conditions, which could aid in industrial biomass conversion technologies.
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