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Sökning: WFRF:(Scott S.) > Södertörns högskola

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1.
  • Rich, Rebecca L., et al. (författare)
  • A global benchmark study using affinity-based biosensors
  • 2009
  • Ingår i: Analytical Biochemistry. - : Elsevier BV. - 0003-2697 .- 1096-0309. ; 386:2, s. 194-216
  • Tidskriftsartikel (refereegranskat)abstract
    • To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione S-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times. Although most participants collected binding responses that could be fit to yield kinetic parameters, the quality of a few data sets could have been improved by optimizing the assay design. Once these outliers were removed, the average reported affinity across the remaining panel of participants was 620 pM with a standard deviation of 980 pM. These results demonstrate that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used.
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2.
  • Lomborg, S., et al. (författare)
  • Automated decision-making : Toward a people-centred approach
  • 2023
  • Ingår i: Sociology Compass. - : John Wiley & Sons. - 1751-9020. ; 17:8
  • Forskningsöversikt (refereegranskat)abstract
    • Recently, automated decision-making (ADM) has been increasingly introduced in for example, the public sector potentially ensuring efficiency and more just decision-making. The increasing use of ADM has been reflected by a growing interest by scholarly research. While initially mainly researchers within law and computer sciences engaged with ADM, there has also been a growing engagement by social science and humanities-oriented researchers. This article traces the emergence and evolution of ADM research beyond computer sciences and engineering with a specific focus on social sciences and humanities by identifying central concerns and methods while outlining a stable baseline for future research. Based on a systematic mapping of publications, we outline the contours of ADM as an area of research engaging with an emerging empirical phenomenon. Drawing on findings from the mapping, we discuss ways ahead for ADM research as part of the subfield of digital sociology and suggest that sociological media and communication studies have a crucial role to play in developing future research avenues. Drawing on advances made in audience research, we suggest a radically contextualized and people-centered approach to ADM. Such an approach would help to develop ADM and ground it alongside people's divergent capabilities and contextual arrangements. 
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