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Sökning: WFRF:(Sediva A)

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  • Sediva, A, et al. (författare)
  • Europe Immunoglobulin Map
  • 2014
  • Ingår i: JOURNAL OF CLINICAL IMMUNOLOGY. - 0271-9142. ; 34, s. S155-S156
  • Konferensbidrag (övrigt vetenskapligt)
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  • Stechova, Katerina, et al. (författare)
  • Case report: type 1 diabetes in monozygotic quadruplets
  • 2012
  • Ingår i: European Journal of Human Genetics. - : Nature Publishing Group. - 1018-4813 .- 1476-5438. ; 20:4, s. 457-462
  • Tidskriftsartikel (refereegranskat)abstract
    • Type 1 diabetes (T1D) is an autoimmune disease characterized by the lack of insulin due to an autoimmune destruction of pancreatic beta cells. Here, we report a unique case of a family with naturally conceived quadruplets in which T1D was diagnosed in two quadruplets simultaneously. At the same time, the third quadruplet was diagnosed with the pre-diabetic stage. Remarkably, all four quadruplets were positive for anti-islet cell antibodies, GAD65 and IA-A2. Monozygotic status of the quadruplets was confirmed by testing 14 different short tandem repeat polymorphisms. Serological examination confirmed that all quadruplets and their father suffered from a recent enteroviral infection of EV68-71 serotype. To assess the nature of the molecular pathological processes contributing to the development of diabetes, immunocompetent cells isolated from all family members were characterized by gene expression arrays, immune-cell enumerations and cytokine-production assays. The microarray data provided evidence that viral infection, and IL-27 and IL-9 cytokine signalling contributed to the onset of T1D in two of the quadruplets. The propensity of stimulated immunocompetent cells from non-diabetic members of the family to secrete high level of IFN-alpha further corroborates this conclusion. The number of T regulatory cells as well as plasmacytoid and/or myeloid dendritic cells was found diminished in all family members. Thus, this unique family is a prime example for the support of the so-called fertile-field hypothesis proposing that genetic predisposition to anti-islet autoimmunity is fertilized and precipitated by a viral infection leading to a fully blown T1D.
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  • Sediva, A, et al. (författare)
  • Europe immunoglobulin map
  • 2014
  • Ingår i: Clinical and experimental immunology. - 1365-2249. ; 178178 Suppl 1, s. 141-143
  • Tidskriftsartikel (refereegranskat)
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  • Resultat 1-8 av 8

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