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Prediction of early...
Prediction of early-stage melanoma recurrence using clinical and histopathologic features
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- Wan, Guihong (författare)
- Harvard Medical School
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- Nguyen, Nga (författare)
- Harvard Medical School
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- Liu, Feng (författare)
- Stevens Institute of Technology
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visa fler...
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- DeSimone, Mia S. (författare)
- Harvard Medical School
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- Leung, Bonnie W. (författare)
- Harvard Medical School
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- Rajeh, Ahmad (författare)
- Harvard Medical School
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- Collier, Michael R. (författare)
- Harvard Medical School
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- Choi, Min Seok (författare)
- Harvard Medical School
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- Amadife, Munachimso (författare)
- Harvard Medical School
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- Tang, Kimberly (författare)
- Harvard Medical School
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- Zhang, Shijia (författare)
- Harvard Medical School
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- Phillipps, Jordan S. (författare)
- Harvard Medical School
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- Jairath, Ruple (författare)
- Harvard Medical School
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- Alexander, Nora A. (författare)
- Harvard Medical School
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- Hua, Yining (författare)
- Harvard Medical School
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- Jiao, Meng (författare)
- Stevens Institute of Technology
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- Chen, Wenxin (författare)
- Harvard Medical School
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- Ho, Diane (författare)
- Harvard Medical School
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- Duey, Stacey (författare)
- Harvard Medical School
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- Németh, István Balázs (författare)
- University of Szeged
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- Marko-Varga, Gyorgy (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Valdés, Jeovanis Gil (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Clinical Chemistry, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Liu, David (författare)
- Dana-Farber Cancer Institute
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- Boland, Genevieve M. (författare)
- Harvard Medical School
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- Gusev, Alexander (författare)
- Dana-Farber Cancer Institute
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- Sorger, Peter K. (författare)
- Harvard Medical School
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- Yu, Kun Hsing (författare)
- Harvard Medical School
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- Semenov, Yevgeniy R. (författare)
- Harvard Medical School
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(creator_code:org_t)
- 2022-10-31
- 2022
- Engelska.
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Ingår i: NPJ precision oncology. - : Springer Science and Business Media LLC. - 2397-768X. ; 6:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Prognostic analysis for early-stage (stage I/II) melanomas is of paramount importance for customized surveillance and treatment plans. Since immune checkpoint inhibitors have recently been approved for stage IIB and IIC melanomas, prognostic tools to identify patients at high risk of recurrence have become even more critical. This study aims to assess the effectiveness of machine-learning algorithms in predicting melanoma recurrence using clinical and histopathologic features from Electronic Health Records (EHRs). We collected 1720 early-stage melanomas: 1172 from the Mass General Brigham healthcare system (MGB) and 548 from the Dana-Farber Cancer Institute (DFCI). We extracted 36 clinicopathologic features and used them to predict the recurrence risk with supervised machine-learning algorithms. Models were evaluated internally and externally: (1) five-fold cross-validation of the MGB cohort; (2) the MGB cohort for training and the DFCI cohort for testing independently. In the internal and external validations, respectively, we achieved a recurrence classification performance of AUC: 0.845 and 0.812, and a time-to-event prediction performance of time-dependent AUC: 0.853 and 0.820. Breslow tumor thickness and mitotic rate were identified as the most predictive features. Our results suggest that machine-learning algorithms can extract predictive signals from clinicopathologic features for early-stage melanoma recurrence prediction, which will enable the identification of patients that may benefit from adjuvant immunotherapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- Av författaren/redakt...
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Wan, Guihong
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Nguyen, Nga
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Liu, Feng
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DeSimone, Mia S.
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Leung, Bonnie W.
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Rajeh, Ahmad
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visa fler...
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Collier, Michael ...
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Choi, Min Seok
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Amadife, Munachi ...
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Tang, Kimberly
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Zhang, Shijia
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Phillipps, Jorda ...
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Jairath, Ruple
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Alexander, Nora ...
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Hua, Yining
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Jiao, Meng
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Chen, Wenxin
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Ho, Diane
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Duey, Stacey
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Németh, István B ...
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Marko-Varga, Gyo ...
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Valdés, Jeovanis ...
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Liu, David
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Boland, Geneviev ...
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Gusev, Alexander
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Sorger, Peter K.
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Yu, Kun Hsing
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Semenov, Yevgeni ...
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