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1.	Kanai, M, et al. (author) 2023 swepub:Mat__t
2.	Tabassum, R, et al. (author) Genetic architecture of human plasma lipidome and its link to cardiovascular disease 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329- Journal article (peer-reviewed)abstract Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
3.	Yu, DM, et al. (author) Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD 2015 In: The American journal of psychiatry. - : American Psychiatric Association Publishing. - 1535-7228 .- 0002-953X. ; 172:1, s. 82-93 Journal article (peer-reviewed)

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Wu, Y. (2); Brown, J. (1); Chen, H. (1); Chen, X. (1); Clark, A. (1); Cole, S. (1); show more...; Davies, M. (1); Endo, M. (1); Erdmann, J. (1); Fox, H. (1); George, S. (1); Hasegawa, Y. (1); Hoffman, J. (1); Hughes, G. (1); Jackson, M. (1); Jackson, P. (1); Karthik, K. (1); Kirk, J. (1); Lee, H. (1); Lewis, A. (1); Maeno, T. (1); Saleem, M. (1); Stern, S. (1); Strauss, E. (1); Suzuki, Y. (1); Walker, R. (1); Wang, C. (1); Watts, S. (1); White, S. (1); Williams, S. (1); Willis, C. (1); Wilson, A. (1); Wright, M. (1); Yamada, M. (1); Liu, J. (1); Nagata, K. (1); Davidson, N. (1); Dobson, E. (1); Harvey, A. (1); Lange, C. (1); Oliveira, M. (1); Owen, S. (1); Rose, A. (1); Taylor, C. (1); Williams, E. (1); Davies, E. (1); Grau, N. (1); Haider, S. (1); Ryan, P. (1); Wright, C. (1); show less...

University: Karolinska Institutet (3)

Language: English (3)

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