| 1. |
- Tabassum, R, et al.
(författare)
-
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- 2019
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329-
-
Tidskriftsartikel (refereegranskat)abstract
- Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
|
|
| 2. |
- Hakeem, Ibrahim Y., et al.
(författare)
-
Crashworthiness performance of filament wound GFRP composite pipes depending on winding angle and number of layers
- 2024
-
Ingår i: Case Studies in Construction Materials. - : Elsevier. - 2214-5095. ; 20
-
Tidskriftsartikel (refereegranskat)abstract
- The main goal of this study is to increase the crashworthiness performance of tubular composite to absorb more energy by optimizing the orientation of its fibers. The crashworthiness performance of glass fiber-reinforced polymer (GFRP) composite pipes manufactured using the filament winding process is investigated in detail. The effects of fiber orientation and thickness of tube wall on energy absorption capabilities were investigated through quasi-static compression tests. The composite pipes were produced with 1200 tex E-glass fibers and Epikote 828 resin as the matrix material. The winding angles of ±30°, ±45°, ±55°, ±75°, and ±90° were examined, and the number of winding layers ranged from 1 to 3 were also examined. Quasi-static axial compressive loading was applied to 15 specimens using a hydraulic actuator. The results revealed that single-layered samples experienced buckling damage at low load levels, while an increase in the number of layers led to higher load-carrying capacity and different types of damage. Furthermore, as the number of layers increased, the load-carrying capacity and energy absorption capacity significantly improved. Progressive failure was observed in [±90°] wound samples for all layer configurations, with [±90°]3 exhibiting the highest performance in terms of load-carrying capacity and energy absorption. The damaged shapes indicated a combination of fiber separation, buckling, diagonal shearing failure, and crushing in the upper and lower heads.
|
|
| 3. |
- Madenci, Emrah, et al.
(författare)
-
Behavior of functionally graded carbon nanotube reinforced composite sandwich beams with pultruded GFRP core under bending effect
- 2024
-
Ingår i: Frontiers in Materials. - : Frontiers. - 2296-8016. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- A novel generation of composite sandwich beams with laminated carbon fiber-reinforced polymer skins and pultruded glass fiber-reinforced polymer core materials was examined for their flexural behavior. The strength and failure mechanisms of the composite sandwich beams in flatwise and edgewise configurations were investigated using three-point static bending tests. These sophisticated composite structures must be designed and used in a variety of sectors, and our research provides vital insights into their performance and failure patterns. In comparison to the reference specimens (FGM-1), the carbon nanotube-reinforced specimens’ bending capacity was affected and ranged from −2.5% to 7.75%. The amount of the carbon nanotube addition had a substantial impact on the beams’ application level and load-carrying capacity. Particularly, the application of 0.5 wt% additive in the outermost fiber region of the beams, such as in FGM-4, led to an increase in the bending capacity. However, the stiffness values at the maximum load were decreased by 0.3%–18.6% compared to FGM-1, with the minimum level of the decrease in FGM-4. The experimental results were compared with the theoretical calculations based on the high-order shear deformation theory, which yielded an approximation between 11.99% and 12.98% by applying the Navier’s solution.
|
|
| 4. |
- Madenci, Emrah, et al.
(författare)
-
Experimental investigation and analytical verification of buckling of functionally graded carbon nanotube-reinforced sandwich beams
- 2024
-
Ingår i: Heliyon. - : Elsevier. - 2405-8440. ; 10:8
-
Tidskriftsartikel (refereegranskat)abstract
- Carbon nanotube (CNT) reinforcement can lead to a new way to enhance the properties of composites by transforming the reinforcement phases into nanoscale fillers. In this study, the buckling response of functionally graded CNT-reinforced composite (FG-CNTRC) sandwich beams was investigated experimentally and analytically. The top and bottom plates of the sandwich beams were composed of carbon fiber laminated composite layers and hard core. The hard core was made of a pultruded glass fiber-reinforced polymer (GFRP) profile. The layers of FG-CNTRC surfaces were reinforced with different proportions of CNT. The reference sample was made of only a pultruded GFRP profile. In the study, the reference sample and four samples with CNT were tested under compression. The largest buckling load difference between the reference sample and the sample with CNT was 37.7%. The difference between the analytical calculation results and experimental results was obtained with an approximation of 0.49%–4.92%. Finally, the buckling, debonding, interlaminar cracks, and fiber breakage were observed in the samples.
|
|
| 5. |
- Murzin, D. Yu., et al.
(författare)
-
Arabinogalactan hydrolysis and hydrolytic hydrogenation usingfunctionalized carbon materials
- 2015
-
Ingår i: Catalysis Today. - : Elsevier BV. - 0920-5861 .- 1873-4308. ; 257, s. 169-176
-
Tidskriftsartikel (refereegranskat)abstract
- Hydrolysis of the hemicellulose arabinogalactan was studied in this work over several functionalized carbon materials, which were specifically treated to increase their acidities. Hydrolytic hydrogenation of arabinogalactan was investigated using the same materials in a mechanical mixture with ruthenium supported on active carbon. Application of these mixtures resulted in formation of polyols, suppressing simultaneously the generation of side products hydroxymethylfurfural (HMF) and furfural. Formation of high molecular weight compounds (aggregates of sugars and humins) was still quite substantial with a mechanical mixture of Ru/C and a carbon material prepared from sucrose by activation with zinc chloride to increase porosity. Post-treatment of this carbonaceous material with sulphuric acid significantly influenced kinetics of high molecular weight products formation resulting also in elevation of sugar alcohols yields.
|
|
