| 1. |
- Sandling, Johanna K., et al.
(författare)
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A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
- 2011
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Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 19:4, s. 479-484
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Tidskriftsartikel (refereegranskat)abstract
- Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease in which the type I interferon pathway has a crucial role. We have previously shown that three genes in this pathway, IRF5, TYK2 and STAT4, are strongly associated with risk for SLE. Here, we investigated 78 genes involved in the type I interferon pathway to identify additional SLE susceptibility loci. First, we genotyped 896 single-nucleotide polymorphisms in these 78 genes and 14 other candidate genes in 482 Swedish SLE patients and 536 controls. Genes with P<0.01 in the initial screen were then followed up in 344 additional Swedish patients and 1299 controls. SNPs in the IKBKE, TANK, STAT1, IL8 and TRAF6 genes gave nominal signals of association with SLE in this extended Swedish cohort. To replicate these findings we extracted data from a genomewide association study on SLE performed in a US cohort. Combined analysis of the Swedish and US data, comprising a total of 2136 cases and 9694 controls, implicates IKBKE and IL8 as SLE susceptibility loci (P(meta)=0.00010 and P(meta)=0.00040, respectively). STAT1 was also associated with SLE in this cohort (P(meta)=3.3 × 10(-5)), but this association signal appears to be dependent of that previously reported for the neighbouring STAT4 gene. Our study suggests additional genes from the type I interferon system in SLE, and highlights genes in this pathway for further functional analysis.
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| 2. |
- Sigurdsson, Gunnar, et al.
(författare)
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Bosonic realizations of the colour Heisenberg Lie algebra
- 2006
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Ingår i: Journal of Nonlinear Mathematical Physics. - : Springer Science and Business Media LLC. - 1402-9251 .- 1776-0852. ; 13, s. 110-128
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Tidskriftsartikel (refereegranskat)abstract
- We describe realizations of the colour analogue of the Heisenberg Lie algebra by power series in non-commuting indeterminates satisfying Heisenberg's canonical commutation relations of quantum mechanics. The obtained formulas are used to construct new operator representations of the colour Heisenberg Lie algebra. These representations are shown to be closely connected with some combinatorial identities and functional difference-differential interpolation formulae involving Euler numbers.
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| 3. |
- Sigurdsson, Gunnar, et al.
(författare)
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Graded quasi-Lie algebras of Witt type
- 2006
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Ingår i: Czechoslovak Journal of Physics. - : Springer Science and Business Media LLC. - 0011-4626 .- 1572-9486. ; 56:10-11, s. 1287-1291
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we introduce a new class of graded algebras called quasi-Lie algebras of Witt type. These algebras can be seen as a generalization of other Witt-type algebras like Lie algebras of Witt type and their colored version, Lie color algebras of Witt type.
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| 4. |
- Sigurdsson, Gunnar, et al.
(författare)
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Lie Color and Hom-Lie Algebras of Witt Type and Their Central Extensions
- 2009
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Ingår i: GENERALIZED LIE THEORY IN MATHEMATICS, PHYSICS AND BEYOND. - BERLIN : SPRINGER-VERLAG BERLIN. - 9783540853312 - 9783540853329 ; , s. 247-255
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Konferensbidrag (refereegranskat)abstract
- In this article, two classes of Gamma-graded Witt-type algebras, Lie color and hom-Lie algebras of Witt type, are considered. These algebras can be seen as generalizations of Lie algebras of Witt type. One-dimensional central extensions of Lie color and hom-Lie algebras of Witt type are investigated.
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| 5. |
- Larsson, Daniel, et al.
(författare)
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On some almost quadratic algebras coming from twisted derivations
- 2006
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Ingår i: Journal of Nonlinear Mathematical Physics. - 1402-9251 .- 1776-0852. ; 13, s. 76-86
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Tidskriftsartikel (refereegranskat)abstract
- This paper explores the quasi-deformation scheme devised in [1, 3] as applied to the simple Lie algebra sl(2)(F) for specific choices of the involved parameters and underlying algebras. One of the main points of this method is that the quasi-deformed algebra comes endowed with a canonical twisted Jacobi identity. We show in the present article that when the quasi-deformation method is applied to sl(2)(F) one obtains multiparameter families of almost quadratic algebras, and by choosing parameters suitably, sl(2)(F) is quasi-deformed into three-dimensional and four-dimensional Lie algebras and algebras closely resembling Lie superalgebras and colour Lie algebras, this being in stark contrast to the classical deformation schemes where sl(2)(F) is rigid.
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| 6. |
- Larsson, Daniel, et al.
(författare)
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On some almost quadratic algebras coming from twisted derivations
- 2006
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Ingår i: Journal of Nonlinear Mathematical Physics. - : Springer Science and Business Media LLC. - 1402-9251 .- 1776-0852. ; 13, s. 76-86
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Tidskriftsartikel (refereegranskat)abstract
- This paper explores the quasi-deformation scheme devised in [1, 3] as applied to the simple Lie algebra sl(2)(F) for specific choices of the involved parameters and underlying algebras. One of the main points of this method is that the quasi-deformed algebra comes endowed with a canonical twisted Jacobi identity. We show in the present article that when the quasi-deformation method is applied to sl(2)(F) one obtains multiparameter families of almost quadratic algebras, and by choosing parameters suitably, sl(2)(F) is quasi-deformed into three-dimensional and four-dimensional Lie algebras and algebras closely resembling Lie superalgebras and colour Lie algebras, this being in stark contrast to the classical deformation schemes where sl(2)(F) is rigid.
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| 7. |
- Gaulton, Kyle J, et al.
(författare)
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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
- 2015
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:12, s. 1415-1415
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Tidskriftsartikel (refereegranskat)abstract
- We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
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| 8. |
- Larsson, Daniel, et al.
(författare)
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Quasi-Lie deformations on the algebra F[t]/(tn)
- 2008
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Ingår i: Journal of Generalized Lie Theory and Applications. - 1736-5279 .- 1736-4337. ; 2:3, s. 201-205
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Tidskriftsartikel (refereegranskat)abstract
- This paper explores the quasi-deformation scheme devised by Hartwig, Larsson and Silvestrov as applied to the simple Lie algebra sl2(F). One of the main points of this method is that the quasi-deformed algebra comes endowed with a canonical twisted Jacobi identity. We show in the present article that when the quasi-deformation method is applied to sl2(F) via representations by twisted derivations on the algebra F[t]/(tN) one obtains interesting new multi-parameter families of almost quadratic algebras.
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| 9. |
- Oei, Ling, et al.
(författare)
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A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus
- 2014
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Ingår i: Journal of Medical Genetics. - : BMJ Publishing Group. - 0022-2593 .- 1468-6244. ; 51:2, s. 122-131
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Osteoporosis is a systemic skeletal disease characterised by reduced bone mineral density and increased susceptibility to fracture; these traits are highly heritable. Both common and rare copy number variants (CNVs) potentially affect the function of genes and may influence disease risk.AIM: To identify CNVs associated with osteoporotic bone fracture risk.METHOD: We performed a genome-wide CNV association study in 5178 individuals from a prospective cohort in the Netherlands, including 809 osteoporotic fracture cases, and performed in silico lookups and de novo genotyping to replicate in several independent studies.RESULTS: A rare (population prevalence 0.14%, 95% CI 0.03% to 0.24%) 210 kb deletion located on chromosome 6p25.1 was associated with the risk of fracture (OR 32.58, 95% CI 3.95 to 1488.89; p=8.69×10(-5)). We performed an in silico meta-analysis in four studies with CNV microarray data and the association with fracture risk was replicated (OR 3.11, 95% CI 1.01 to 8.22; p=0.02). The prevalence of this deletion showed geographic diversity, being absent in additional samples from Australia, Canada, Poland, Iceland, Denmark, and Sweden, but present in the Netherlands (0.34%), Spain (0.33%), USA (0.23%), England (0.15%), Scotland (0.10%), and Ireland (0.06%), with insufficient evidence for association with fracture risk.CONCLUSIONS: These results suggest that deletions in the 6p25.1 locus may predispose to higher risk of fracture in a subset of populations of European origin; larger and geographically restricted studies will be needed to confirm this regional association. This is a first step towards the evaluation of the role of rare CNVs in osteoporosis.
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| 10. |
- Scott, Robert A., et al.
(författare)
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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
- 2017
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 66:11, s. 2888-2902
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Tidskriftsartikel (refereegranskat)abstract
- To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P < 5 x 10(-8)), including variants near the GLP2R, GIP, and HLA-DQA1 genes. Our analysis brought the total number of independent T2D associations to 128 distinct signals at 113 loci. Despite substantially increased sample size and more complete coverage of low-frequency variation, all novel associations were driven by common single nucleotide variants. Credible sets of potentially causal variants were generally larger than those based on imputation with earlier reference panels, consistent with resolution of causal signals to common risk haplotypes. Stratification of T2D-associated loci based on T2D-related quantitative trait associations revealed tissue-specific enrichment of regulatory annotations in pancreatic islet enhancers for loci influencing insulin secretion and in adipocytes, monocytes, and hepatocytes for insulin action-associated loci. These findings highlight the predominant role played by common variants of modest effect and the diversity of biological mechanisms influencing T2D pathophysiology.
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