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- Wilcox, K. S., et al.
(författare)
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Issues related to development of new antiseizure treatments
- 2013
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Ingår i: Epilepsia. - : Wiley. - 0013-9580. ; 54, s. 24-34
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Tidskriftsartikel (refereegranskat)abstract
- This report represents a summary of the discussions led by the antiseizure treatment working group of the International League Against Epilepsy (ILAE)/American Epilepsy Society (AES) Working Groups joint meeting in London (London Meeting). Wereview here what is currently known about the pharmacologic characteristics of current models of refractory seizures, both for adult and pediatric epilepsy. In addition, we address how the National Institute of Neurological Disorders and Stroke (NINDS)-funded Anticonvulsant Screening Program (ASP) is evolving to incorporate appropriate animal models in the search for molecules that might be sufficiently novel to warrant further pharmacologic development. Wealso briefly address what we believe is necessary, going forward, to achieve the goal of stopping seizures in all patients, with a call to arms for funding agencies, the pharmaceutical industry, and basic researchers.
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| 2. |
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| 3. |
- Jeuland, M., et al.
(författare)
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Is energy the golden thread? A systematic review of the impacts of modern and traditional energy use in low- and middle-income countries
- 2021
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Ingår i: Renewable and Sustainable Energy Reviews. - : Elsevier BV. - 1364-0321. ; 135
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Tidskriftsartikel (refereegranskat)abstract
- Energy has been called the “golden thread” that connects economic growth, social equity and environmental sustainability, but important knowledge gaps exist on the impacts of low- and middle-income country energy interventions and transitions. This study offers perhaps the broadest characterization to date of the patterns and consistency in quantitative and peer-reviewed social science literature considering such impacts. Starting from approximately 80,000 papers identified using a search procedure organized along energy services, technology, and impact dimensions, and structured to achieve breadth and replicability, articles were first screened to yield a relevant subset of 3,000 quantitative papers. Relevance is defined as providing one or more types of impacts on intra-household, household, firm, public service, national economy, or environmental outcomes. A set of heat maps highlights areas of concentration in the literature, namely work that emphasizes the negative health and pollution effects of traditional cooking and fossil fuel use. The extent and consistency of evidence for different types of impacts (in terms of direction and statistical significance) is also discussed, which reveals considerable heterogeneity and highlights important knowledge gaps that remain despite rapidly expanding energy scholarship. The patterns of evidence are also surprisingly consistent across methods. The article concludes by articulating several research challenges that should motivate current and future generations of energy and development scholars. © 2020 Elsevier Ltd
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| 5. |
- Nicoletti, Paola, et al.
(författare)
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Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions
- 2019
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Ingår i: Clinical Pharmacology and Therapeutics. - : John Wiley & Sons. - 0009-9236 .- 1532-6535. ; 106:5, s. 1028-1036
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Tidskriftsartikel (refereegranskat)abstract
- Carbamazepine (CBZ) causes life-threating T-cell-mediated hypersensitivity reactions, including serious cutaneous adverse reactions (SCARs) and drug-induced liver injury (CBZ-DILI). In order to evaluate shared or phenotype-specific genetic predisposing factors for CBZ hypersensitivity reactions, we performed a meta-analysis of two genomewide association studies (GWAS) on a total of 43 well-phenotyped Northern and Southern European CBZ-SCAR cases and 10,701 population controls and a GWAS on 12 CBZ-DILI cases and 8,438 ethnically matched population controls. HLA-A*31:01 was identified as the strongest genetic predisposing factor for both CBZ-SCAR (odds ratio (OR) = 8.0; 95% CI 4.10-15.80; P = 1.2 x 10(-9)) and CBZ-DILI (OR = 7.3; 95% CI 2.47-23.67; P = 0.0004) in European populations. The association with HLA-A*31:01 in patients with SCAR was mainly driven by hypersensitivity syndrome (OR = 12.9; P = 2.1 x 10(-9)) rather than by Stevens-Johnson syndrome/toxic epidermal necrolysis cases, which showed an association with HLA-B*57:01. We also identified a novel risk locus mapping to ALK only for CBZ-SCAR cases, which needs replication in additional cohorts and functional evaluation.
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| 6. |
- Patricios, Jon S., et al.
(författare)
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Implementation of the 2017 Berlin Concussion in Sport Group Consensus Statement in contact and collision sports: a joint position statement from 11 national and international sports organisations
- 2018
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Ingår i: British Journal of Sports Medicine. - : BMJ PUBLISHING GROUP. - 0306-3674 .- 1473-0480. ; 52:10, s. 635-641
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Tidskriftsartikel (refereegranskat)abstract
- The 2017 Berlin Concussion in Sport Group Consensus Statement provides a global summary of best practice in concussion prevention, diagnosis and management, underpinned by systematic reviews and expert consensus. Due to their different settings and rules, individual sports need to adapt concussion guidelines according to their specific regulatory environment. At the same time, consistent application of the Berlin Consensus Statements themes across sporting codes is likely to facilitate superior and uniform diagnosis and management, improve concussion education and highlight collaborative research opportunities. This document summarises the approaches discussed by medical representatives from the governing bodies of 10 different contact and collision sports in Dublin, Ireland in July 2017. Those sports are: American football, Australian football, basketball, cricket, equestrian sports, football/soccer, ice hockey, rugby league, rugby union and skiing. This document had been endorsed by 11 sport governing bodies/national federations at the time of being published.
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| 7. |
- Singh, R. N., et al.
(författare)
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Modeling of temperature dependence of stress-reorientation of hydrides in CWSR Zr-alloys
- 2008
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Ingår i: Defect and Diffusion Forum. ; :279, s. 105-110
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Tidskriftsartikel (refereegranskat)abstract
- Hydrogen in excess of solid solubility precipitates as hydride phase of plate shaped morphology in hcp α-Zr with the broad face of the hydride plate coinciding with certain crystallographic plane of α-Zr crystal called habit plane. The objective of the present investigation is to predict the habit plane of δ-hydride precipitating in α-Zr at 298 K using strain energy minimization technique. The δ-hydride phase is modeled to undergo isotropic elasto-plastic deformation. The α-Zr phase was modeled to undergo transverse isotropic elastic deformation but isotropic plastic deformation. Accommodation strain energy of δ-hydride forming in α-Zr crystal was computed using initial strain method as a function of hydride nuclei orientation. Hydride was modeled as disk with round edge. Contrary to several habit planes reported in literature for δ- hydrides precipitating in α-Zr crystal, the total accommodation energy minima at 298 K suggests only basal plane i.e. (0001) as the habit plane.
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