SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Silverman J M) "

Search: WFRF:(Silverman J M)

  • Result 1-10 of 117
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Vogel, Jacob W., et al. (author)
  • Four distinct trajectories of tau deposition identified in Alzheimer’s disease
  • 2021
  • In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:5, s. 871-881
  • Journal article (peer-reviewed)abstract
    • Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 117
Type of publication
journal article (107)
research review (6)
conference paper (4)
Type of content
peer-reviewed (113)
other academic/artistic (4)
Author/Editor
Kraft, Peter (15)
Albanes, Demetrius (14)
Riboli, Elio (13)
Chanock, Stephen J (13)
Kogevinas, Manolis (13)
Canzian, Federico (12)
show more...
Zheng, Wei (12)
Duell, Eric J. (12)
Jacobs, Eric J (12)
Bracci, Paige M (12)
Krogh, Vittorio (11)
Sullivan, PF (11)
Hultman, CM (11)
Giles, Graham G (11)
White, Emily (11)
Peters, Ulrike (11)
Bueno-de-Mesquita, H ... (11)
Shu, Xiao-Ou (11)
Chatterjee, Nilanjan (11)
Hunter, David J (11)
Neale, BM (11)
Yu, Kai (11)
Agartz, I (10)
Andreassen, OA (10)
Melle, I (10)
Pato, MT (10)
Rujescu, D (10)
Werge, T (10)
Sollerman, Jesper (10)
Haiman, Christopher ... (10)
Berndt, Sonja I (10)
Mattheisen, M (10)
Morris, DW (10)
Levinson, DF (10)
Schulze, TG (10)
Ripke, S (10)
Gallinger, Steven (10)
Visvanathan, Kala (10)
Severi, Gianluca (10)
Garcia-Closas, Monts ... (10)
Palotie, A (10)
Shi, JX (10)
Sklar, P (10)
Brennan, Paul (10)
Cloninger, CR (10)
Olson, Sara H. (10)
Bergen, SE (10)
Petersen, Gloria M (10)
Arslan, Alan A (10)
Hutchinson, Amy (10)
show less...
University
Karolinska Institutet (54)
Umeå University (26)
Stockholm University (24)
Uppsala University (18)
University of Gothenburg (16)
Lund University (16)
show more...
Linköping University (4)
Jönköping University (1)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
show less...
Language
English (117)
Research subject (UKÄ/SCB)
Medical and Health Sciences (55)
Natural sciences (30)
Social Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view