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| 2. |
- Halamoda-Kenzaoui, Blanka, et al.
(författare)
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Bridging communities in the field of nanomedicine
- 2019
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Ingår i: Regulatory toxicology and pharmacology. - : Elsevier BV. - 0273-2300 .- 1096-0295. ; 106, s. 187-196
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Tidskriftsartikel (refereegranskat)abstract
- An early dialogue between nanomedicine developers and regulatory authorities are of utmost importance to anticipate quality and safety requirements for these innovative health products. In order to stimulate interactions between the various communities involved in a translation of nanomedicines to clinical applications, the European Commission's Joint Research Centre hosted a workshop titled "Bridging communities in the field of Nanomedicine" in Ispra/Italy on the 27th -28th September 2017. Experts from regulatory bodies, research institutions and industry came together to discuss the next generation of nanomedicines and their needs to obtain regulatory approval. The workshop participants came up with recommendations highlighting methodological gaps that should be addressed in ongoing projects addressing the regulatory science of nanomedicines. In addition, individual opinions of experts relevant to progress of the regulatory science in the field of nanomedicine were summarised in the format of a survey.
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| 3. |
- Schon, K., et al.
(författare)
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Intercomparison on PD calibrators and PD instruments
- 1999
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Ingår i: IEE Conference Publication. - : Institute of Electrical and Electronics Engineers (IEEE). - 0852967195 ; , s. 1.5.S1-1.8.S1
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Konferensbidrag (refereegranskat)abstract
- Within the framework of a European project, two partial discharge calibrators were circulated to thirteen laboratories for an intercomparison of impulse charge measurements in the range between 1 pC and 500 pC. The deviations of the charge values q reported by the laboratories were, with a very few exceptions, within ±(0.1 pC+0.03·q). Furthermore, the characteristics of several partial discharge measuring instruments were investigated. The indication of some of the instruments showed deviations of more than ten percent from the correct values.
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- Berto, Marcello, et al.
(författare)
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Label free urea biosensor based on organic electrochemical transistors
- 2018
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Ingår i: Flexible and Printed Electronics. - : IOP Publishing. - 2058-8585. ; 3:2
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Tidskriftsartikel (refereegranskat)abstract
- The quantification of urea is of the utmost importance not only in medical diagnosis, where it serves as a potential indicator of kidney and liver disfunction, but also in food safety and environmental control. Here, we describe a urea biosensor based on urease entrapped in a crosslinked gelatin hydrogel, deposited onto a fully printed PEDOT:PSS-based organic electrochemical transistor (OECT). The device response is based on the modulation of the channel conductivity by the ionic species produced upon urea hydrolysis catalyzed by the entrapped urease. The biosensor shows excellent reproducibility, a limit of detection as low as 1 μM and a response time of a few minutes. The fabrication of the OECTs by screen-printing on flexible substrates ensures a significant reduction in manufacturing time and costs. The low dimensionality and operational voltages (0.5 V or below) of these devices contribute to make these enzymatic OECT-based biosensors as appealing candidates for high-throughput monitoring of urea levels at the point-of-care or in the field.
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| 8. |
- Hithnawi, A., et al.
(författare)
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Poster abstract : Cross-layer optimization for low-power wireless coexistence
- 2015
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Ingår i: SenSys 2015 - Proceedings of the 13th ACM Conference on Embedded Networked Sensor Systems. - New York, NY, USA : ACM Digital Library. - 9781450336314 ; , s. 443-444
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Konferensbidrag (refereegranskat)abstract
- We present a system that leverages physical layer features to combat Cross-Technology Interference (CTI) in low-power wireless networks. Our system incorporates: (i) a lightweight interference detection mechanism for low-power radios that recognizes the type of interference in the received signal, (ii) a lightweight error detection mechanism to estimate and characterize error patterns within interfered packets, and (iii) a CTI-aware protocol that dynamically adapts transmission and recovery mode to the current interference patterns. We implement a prototype of our system for the lowpower IEEE 802.15.4 in software defined radios (SDR). Our early results of the system components demonstrate that we can achieve a high accuracy in error detection and interference type identification. Moreover, we observed a significant performance improvement compared to the standard 802.15.4 systems without interference-awareness.
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| 9. |
- Jonsson, Amanda, et al.
(författare)
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Therapy using implanted organic bioelectronics
- 2015
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Ingår i: Science Advances. - : American Association for the Advancement of Science. - 2375-2548. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Many drugs provide their therapeutic action only at specific sites in the body, but are administered in ways that cause the drug’s spread throughout the organism. This can lead to serious side effects. Local delivery from an implanted device may avoid these issues, especially if the delivery rate can be tuned according to the need of the patient. We turned to electronically and ionically conducting polymers to design a device that could be implanted and used for local electrically controlled delivery of therapeutics. The conducting polymers in our device allow electronic pulses to be transduced into biological signals, in the form of ionic and molecular fluxes, which provide a way of interfacing biology with electronics. Devices based on conducting polymers and polyelectrolytes have been demonstrated in controlled substance delivery to neural tissue, biosensing, and neural recording and stimulation. While providing proof of principle of bioelectronic integration, such demonstrations have been performed in vitro or in anesthetized animals. Here, we demonstrate the efficacy of an implantable organic electronic delivery device for the treatment of neuropathic pain in an animal model. Devices were implanted onto the spinal cord of rats, and 2 days after implantation, local delivery of the inhibitory neurotransmitter g-aminobutyric acid (GABA) was initiated. Highly localized delivery resulted in a significant decrease in pain response with low dosage and no observable side effects. This demonstration of organic bioelectronics-based therapy in awake animals illustrates a viable alternative to existing pain treatments, paving the way for future implantable bioelectronic therapeutics. 2015 © The Authors.
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