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- Halamoda-Kenzaoui, Blanka, et al.
(författare)
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Bridging communities in the field of nanomedicine
- 2019
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Ingår i: Regulatory toxicology and pharmacology. - : Elsevier BV. - 0273-2300 .- 1096-0295. ; 106, s. 187-196
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Tidskriftsartikel (refereegranskat)abstract
- An early dialogue between nanomedicine developers and regulatory authorities are of utmost importance to anticipate quality and safety requirements for these innovative health products. In order to stimulate interactions between the various communities involved in a translation of nanomedicines to clinical applications, the European Commission's Joint Research Centre hosted a workshop titled "Bridging communities in the field of Nanomedicine" in Ispra/Italy on the 27th -28th September 2017. Experts from regulatory bodies, research institutions and industry came together to discuss the next generation of nanomedicines and their needs to obtain regulatory approval. The workshop participants came up with recommendations highlighting methodological gaps that should be addressed in ongoing projects addressing the regulatory science of nanomedicines. In addition, individual opinions of experts relevant to progress of the regulatory science in the field of nanomedicine were summarised in the format of a survey.
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| 2. |
- Kovatsch, Matthias, et al.
(författare)
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A Low-Power CoAP for Contiki
- 2011. - 11
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Konferensbidrag (refereegranskat)abstract
- Internet of Things devices will by and large be battery-operated, but existing application protocols have typically not been designed with power-efficiency in mind. In low-power wireless systems, power-efficiency is determined by the ability to maintain a low radio duty cycle: keeping the radio off as much as possible. We present an implementation of the IETF Constrained Application Protocol (CoAP) for the Contiki operating system that leverages the ContikiMAC low-power duty cycling mechanism to provide power efficiency. We experimentally evaluate our low-power CoAP, demonstrating that an existing application layer protocol can be made power-efficient through a generic radio duty cycling mechanism. To the best of our knowledge, our CoAP implementation is the first to provide power-efficient operation through radio duty cycling. Our results question the need for specialized low-power mechanisms at the application layer, instead providing low-power operation only at the radio duty cycling layer.
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| 3. |
- Kovatsch, Matthias, et al.
(författare)
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Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications
- 2012. - 9
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Konferensbidrag (refereegranskat)abstract
- Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that provides Web-like scripting for low-end devices through Cloud-based application servers and a consistent, RESTful programming model. Our novel runtime container Actinium (Ac) exposes scripts, their configuration, and their lifecycle management through a fully RESTful programming interface using the Constrained Application Protocol (CoAP). We endow the JavaScript language with an API for direct interaction with mote-class IoT devices, the CoapRequest object, and means to export script data as Web resources. With Actinium, applications can be created by simply mashing up resources provided by CoAP servers on devices, other scripts, and classic Web services. We also discuss security considerations and show the suitability of this architecture in terms of performance with our publicly available implementation.
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