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- Xia, CY, et al.
(author)
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Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures
- 2020
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In: Frontiers in oncology. - : Frontiers Media SA. - 2234-943X. ; 10, s. 598872-
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Journal article (peer-reviewed)abstract
- We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets with the non-affected triplet. The differences were observed in naïve B-cells and marginal zone-like B-cells. DNA methylation differences were also detected when comparing each of the HL-affected triplets against each other. Even though we cannot determine whether treatment and/or disease triggered the observed differences, we believe our data are important on behalf of forthcoming studies, and that it might provide important clues for a better understanding of HL pathogenesis.
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