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- Larsson, A, et al.
(författare)
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Regional cerebral blood flow in normal individuals aged 40, 75 and 88 years studied by 99Tc(m)-d,l-HMPAO SPET.
- 2001
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Ingår i: Nuclear medicine communications. - 0143-3636. ; 22:7, s. 741-6
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Tidskriftsartikel (refereegranskat)abstract
- Age-related changes in cerebral blood flow (CBF) were examined with [99Tc(m)]-d,l-hexamethylpropylene amine oxime (HMPAO), using a single photon emission tomography (SPET) gamma camera system equipped with a high resolution collimator, in 33 normal individuals in three age groups: 40 years old (n = 11), 75 years old (n = 9) and 88 years old (n = 13). A standard activity of 1000 MBq [99Tc(m)]-d,l-HMPAO was administered. Regional CBF (rCBF) (relative to cerebellar counts) was quantified in 28 grey and white matter regions. The mean rCBF of all the regions was 0.80 (95% confidence interval [CI] 0.77-0.83) in 40 year olds, 0.77 (0.74-0.80) in 75 year olds and 0.76 (0.73-0.78) in 88 year olds. rCBF in the hippocampus, angular and cingular gyri, and frontal association and motor cortices was 5-10% lower in the 75 and 88 year olds than in the middle-aged subjects (P < 0.05). The annual reduction in rCBF was 0.10% between the ages of 40 and 75 years and 0.13% between the ages of 75 and 88 years. The reduction in rCBF in the hippocampus rose from 0.14% between the ages of 40 and 75 years to 0.33% between the ages of 75 and 88 years. The mean rCBF in all 33 individuals showed no sex-related differences.
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| 2. |
- Mehlig, Kirsten, 1964, et al.
(författare)
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Physical Activity, Weight Status, Diabetes and Dementia: A 34-Year Follow-Up of the Population Study of Women in Gothenburg
- 2014
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Ingår i: Neuroepidemiology. - : S. Karger AG. - 0251-5350 .- 1423-0208. ; 42:4, s. 252-259
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is evidence of a synergistic interaction between obesity and sedentary lifestyle with respect to diabetes. Although diabetes is a known risk factor for dementia, it is unclear if both diseases have common aetiologies. Methods: A community-based sample of 1,448 Swedish women, aged 38-60 years and free of diabetes and dementia in 1968, was followed by means of up to 5 examinations spread over 34 years. 9.6% of all women developed diabetes and 11.4% developed dementia (over 40,000 person-years of follow-up for each disease). Cox proportional hazard regression was used to assess the influence of selected risk factors on both diseases, and the relation between diabetes and dementia. Results: Comparing risk factors for incident diabetes and dementia, both diseases showed a synergistic association with obesity combined with a low level of leisure time physical activity [hazard ratio (HR) for interaction = 2.7, 95% confidence interval (Cl) = 1.2-6.3 for diabetes and HR = 3.3, 95% Cl = 1.1-9.9 for dementia]. Development of diabetes doubled the risk for subsequent dementia (HR = 2.2, 95% Cl = 1.1-4.4), which was slightly reduced upon adjustment for common risk factors. Conclusions: Shared risk factors suggest a similar aetiology for diabetes and dementia and partially explain the association between diseases. (C) 2014 S. Karger AG, Basel
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| 3. |
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| 4. |
- Olesen, Pernille J, et al.
(författare)
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The predictive value of cerebral ischemic lesions for dementia
- 2008
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Ingår i: Vas-Cog, Singapore 14-16 Jan 2009.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background & Objective Changes in white matter are known to be related to dementia and cognitive decline. We examined whether CT-detected white matter lesions (WMLs) predicted dementia or cognitive decline in a population followed for five years. Methods A representative sample of persons aged 70-82 years were examined with a neuropsychiatric examination and a CT scan in 2000-2001 (N=657). A follow-up examination was performed in 2005 (N=503). People without dementia at the time of CT scanning and who participated in the examinations in 2005 were included (N=497). The Wahlund scale was used to define WMLs using a score from 0 (no lesions) to 3 (severe lesions). Cognitive status was assessed with the Mini Mental State Examination (MMSE). The difference in MMSE score from 2000 to 2005 (∆MMSE) was used as a general measure on cognitive decline. Differences in performance on other neuropsychiatric tests were included to get more sensitive measures of change in cognitive function. Regression analyses were applied to analyze whether WMLs could predict the outcome of dementia or cognitive decline five years later. Results Thirty-seven people were diagnosed with dementia in 2005 (7.4%), of these 12 (32%) had any WML of severity >1 on the CT performed five years earlier. For the non-demented group the comparable number was 77 (17%). Significant cognitive decline according to ∆MMSE was seen in the group who were diagnosed with dementia. Preliminary regression analysis shows that cognitive decline and parieto-occipital WMLs predicted onset of dementia. Conclusion The findings suggest that WMLs are weak predictors of dementia. Only WMLs in parieto-occipital areas were related to dementia five years later. Further analyses will show the relation between WMLs and decline in cognitive symptoms.
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| 5. |
- Olesen, Pernille J, et al.
(författare)
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White matter lesions in the elderly increases the risk of major depression five years later
- 2009
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Ingår i: IFPE, Wien 16-19 April 2009.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Objective To study the association between ischemic white matter lesions (WMLs) and major depressive episode (MDE) in a population-based sample followed for five years. Methods A randomized sample of non-demented elderly was investigated in 2000-2001 and in 2005-2006 with psychiatric and physical examinations. Among those who participated at baseline (n=914), 813 were alive in 2005 and 681 (84%) took part in the follow-up examination. A computerized tomography (CT) of the head was done on 462 individuals aged 70-86 years at baseline. Women (n=329) were stratified into two age-groups, 70- (n=196) and 78-86-year olds (n=133). WMLs were rated from 0 (none) to 3 (severe). Results The prevalence of MDE was lower in 2000 (3.6%; n=12/329) than in 2005 (7.3%; n=24/329). Moderate to severe WMLs were present in 11.6% (n=38/329). In 70-year old women, WMLs detected in 2000 were associated with an increased risk of having MDE in 2005 (OR=6.98; CI=2.06-23.67; p=0.002). WMLs were not associated with MDE in 2000 or with MDE in those older than 70-years at baseline. Conclusion WMLs in 70-year old women were associated with an increased risk of MDE five years later.
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| 6. |
- Skoog, Ingmar, 1954, et al.
(författare)
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Suicidal feelings in a population sample of nondemented 85-year-olds.
- 1996
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Ingår i: The American journal of psychiatry. - 0002-953X. ; 153:8, s. 1015-20
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The authors studied the 1-month frequency of suicidal feelings among very old people. METHOD: A population sample (N = 345) of nondemented 85-year-olds in Gothenburg, Sweden, were examined by a psychiatrist. Suicidal feelings were rated by the system of Paykel et al. Mental disorders were diagnosed according to DSM-III-R. RESULTS: Of the mentally healthy subjects (N = 225), 4.0% had thought during the last month that life was not worth living, 4.0% had had death wishes, and 0.9% had thought of taking their own lives. None had seriously considered suicide. The figures were higher among subjects with mental disorders (N = 120); 29.2% had thought that life was not worth living, 27.5% had had death wishes, 9.2% had thought about taking their lives, and 1.7% had seriously considered suicide. Among the subjects with mental disorders, including depression, suicidal feelings were associated with greater use of anxiolytics but not of antidepressants. Women who felt that life was not worth living had a higher 3-year mortality rate than did women without these feelings (43.2% versus 14.2%). This finding was independent of concomitant physical and mental disorders. CONCLUSIONS: Mild suicidal feelings are common in elderly subjects with metal disorders but infrequent in the mentally healthy. The substantially higher mortality rate in women who felt that life was not worth living, compared to women who did not, suggests these feelings must be taken seriously. Because of the high suicide rate in the elderly, there is a need for better diagnosis and treatment of mental disorders in this age group.
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