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- Arakawa, H, et al.
(författare)
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Airway responses following intradermal sensitization to different types of allergens: ovalbumin, trimellitic anhydride and Dermatophagoides farinae
- 1995
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Ingår i: International Archives of Allergy and Immunology. - 1423-0097. ; 108:3, s. 274-280
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Tidskriftsartikel (refereegranskat)abstract
- Sensitization of guinea pigs by intradermal injections of the occupational allergen trimellitic anhydride (TMA) in oily vehicle has been shown to be very reproducible. We studied the effect of intradermal sensitization with ovalbumin (OA) in oily vehicle on immune and airway responses in guinea pigs. We also compared airway responses to trimellitic anhydride or Dermatophagoides farinae (DF; mite) with those to OA in guinea pigs intradermally sensitized to respective allergens. Three to four weeks after sensitization, the animals were challenged with intratracheal instillation of these allergens. Intradermal injections with OA developed dose-dependently specific IgG1 antibodies to OA demonstrated by ELISA. In animals sensitized with different doses of OA in corn oil vehicle, a challenge with OA induced a reversely dose-dependent airflow obstruction and airway plasma exudation. In contrast, animals sensitized with OA in saline vehicle had dose-dependent airway responses to OA. Challenge with OA caused an immediate peak and subsequently persistent airflow obstruction, whereas this response to either TMA guinea pig serum albumin or Df was slowly progressive in animals sensitized to respective allergens. The animals sensitized to TMA or Df may show a different profile of airway responses following the challenge compared to OA. Intradermal sensitization may be a valuable method of sensitization for the development of an animal model of airway allergy to different types of allergens, including chemicals or mites.
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| 3. |
- Arakawa, H, et al.
(författare)
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Effect of maturation on airway plasma exudation induced by eicosanoids in guinea pig
- 1994
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Ingår i: European Journal of Pharmacology. - 1879-0712. ; 259:3, s. 251-257
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Tidskriftsartikel (refereegranskat)abstract
- Airway reactivity to bronchoconstrictor mediators changes with age. We studied the effects of maturational change on airway responses induced by a thromboxane A2 mimetic, U-46619 (2, 6 and 20 nmol/kg; i.v.), leukotriene D4 (0.6 and 2 nmol/kg; i.v.) or vehicle (0.9% NaCl; i.v.) in immature (196 +/- 3 g: 2 weeks) and adult guinea pigs (512 +/- 5 g: 11 weeks). In the same animals, we measured both lung resistance (RL) to monitor airflow obstruction and extravasation of Evans Blue dye (20 mg/kg) to quantify airway plasma exudation. For a comparison, changes in RL in response to acetylcholine (5, 15 and 50 nmol/kg; i.v.) were also examined in both age groups. The order of potency to induce an increase in RL did not change with age (leukotriene D4 > U-46619 > acetylcholine). In immature animals, the peak RL after U-46619 (2, 6 and 20 nmol/kg; P < 0.05, P < 0.005 and P < 0.01, respectively) and leukotriene D4 (2 nmol/kg; P < 0.01) was significantly higher than in adult animals. U-46619 and leukotriene D4 produced significant extravasation of Evans Blue dye in both immature and adult animals. The order of potency to induce extravasated dye also did not change with age (leukotriene D4 > U-46619). The amount of extravasation of Evans Blue dye after U-46619 (6 and 20 nmol/kg) and leukotriene D4 (0.6 and 2 nmol/kg) was significantly smaller in immature animals than adults at all airway levels.(ABSTRACT TRUNCATED AT 250 WORDS)
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| 4. |
- Arvidsson, P, et al.
(författare)
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Exudation of plasma and production of thromboxane in human bronchi after local bradykinin challenge
- 2001
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Ingår i: Respiratory Medicine. - : Elsevier BV. - 1532-3064 .- 0954-6111. ; 95:5, s. 313-318
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Tidskriftsartikel (refereegranskat)abstract
- Plasma exudation has been suggested to be an important component of the inflammatory response in asthma. Bradykinin elicits many of the features of asthma, including bronchoconstriction, cough, plasma exudation and mucus secretion. In an attempt to quantify local plasma exudation, we have employed a novel low-trauma technique with the aim of challenging and lavaging a central part of the bronchial tree, by selecting a medium sized bronchus. A fibreoptic bronchoscopy was performed in non-smoking healthy volunteers. The instrument was placed proximally in the right upper lobe bronchus. A plastic catheter, equipped with an inflatable latex balloon, was inflated with air (2-4 cmH2O). A solution (100 microl of either two different concentrations of bradykinin: 0.09 and 0.9 mg ml(-1) or normal saline) was instilled through the catheter and distal to the balloon. Eight minutes later a lavage procedure with 10 ml of saline was performed through the catheter. The procedure was then repeated twice, with the other solutions, but from the lingular and middle lobe bronchi. All solutions were given in a blinded fashion, and two different studies were performed. Lavage concentrations of albumin and IgG were quantified as measurements of plasma exudation. In our first study we found that bradykinin challenge significantly increased concentrations of albumin and IgG. In study two, there was no numeric increase in plasma proteins after local bradykinin challenge, but the concentration of thromboxane was significantly increased in lavages from bradykinin-challenged bronchi. Thus, local bronchial administration of bradykinin has the capacity to induce exudation of large plasma macromolecules into the bronchial lumen, as well as local thromboxane production.
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| 5. |
- Ebenhag, Sven-Christian, 1976, et al.
(författare)
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A fiber based frequency distribution system with enchanced output phase stability
- 2009
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Ingår i: Proceedings EFTF-IFCS2009 joint conference 20-24 April 2009, IEEE catalog number:CFP09FRE-CDR. - 1075-6787. - 9781424435104 ; , s. 1061-1064
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Konferensbidrag (refereegranskat)abstract
- Experimental results on the stability of the output phase of a frequency distribution system from several days of measurement is presented, in addition to a discussion regarding the influence of control loop parameters. The setup handles the issue that the output phase stability of a system depends on perturbations along the transmission length. This is especially critical if the signal is transmitted through optical fiber, at lengths of a few 100 m. An experimental evaluation using a laser based transmitter at a wavelength of 850 nm, and 625 m of multimode fiber where 575 m where placed outdoor, a temperature dependence of 100 ps/°C was detected. Tocompensate for these slow variations in real time, a setup using two-way transmission, in conjunction with an adjustable optical delay, was constructed. This device is adjusted to induce a delay variation of equal magnitude but opposite direction, in comparison to the delay change of the fiber. Calculating the modified Allan deviation of the transmitted signal, it is apparent that without active compensation, the deviation at τ below 1000 s is comparable to the values from the measurement system without transmission. At longer integration times, however, the slow variations in the fiber transmission will deteriorate the modified ADEV substantially. When activating the dynamic adjustment of pre-delay in the system, the deviation at shorter times will increase with a few dB, however, the modified ADEV decreases continuously with τ, eventually below the values for the uncompensated system. In conclusion, activating a dynamically controlled pre-delay in a fiber based frequency transmission system will induce a small penalty on fast variations of the output phase, however giving a remarkable improvement on slower variations. The usefulness of this added functionality must therefore be determined by the application of the signal.
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| 7. |
- Savolainen, P., et al.
(författare)
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Organisational Constraints in Data-driven Maintenance: a case study in the automotive industry
- 2020
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Ingår i: IFAC-PapersOnLine. - : Elsevier BV. - 2405-8963 .- 2405-8963. ; 53:3, s. 95-100
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Konferensbidrag (refereegranskat)abstract
- Technological development and innovations has been the focus of research in the field of smart maintenance, whereas there is less research regarding how maintenance organisations adapt the development. This case study focuses to understand what constraints maintenance organisations in the transition into applying more data-driven decisions in maintenance. This paper aims to emphasize the organisational challenges in data-driven maintenance, such as trustworthiness of data-driven decisions, data quality, management and competences. Through a case study at a global company in the automotive industry these challenges are highlighted and discussed through a questionnaire survey participated by 72 people and interviews with 7 people from the maintenance organisation.
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