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1.
  • Jiang, Xia, et al. (författare)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • Ingår i: Nature Communications. - 2041-1723. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. © 2019, The Author(s).
2.
  • Abazov, V. M., et al. (författare)
  • Measurement of the inclusive jet cross section in p(p)over-bar collisions at root s=1.96 TeV
  • 2012
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 85:5
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present a measurement of the inclusive jet cross section using the Run II cone algorithm and data collected by the D0 experiment in p (p) over bar collisions at a center-of-mass energy root s = 1.96 TeV, corresponding to an integrated luminosity of 0: 70 fb(-1). The jet energy calibration and the method used to extract the inclusive jet cross section are described. We discuss the main uncertainties, which are dominated by the jet energy scale uncertainty. The results cover jet transverse momenta from 50 GeV to 600 GeV with jet rapidities in the range -2.4 to 2.4 and are compared to predictions using recent proton parton distribution functions. Studies of correlations between systematic uncertainties in transverse momentum and rapidity are presented.</p>
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3.
  • Abazov, V. M., et al. (författare)
  • Muon reconstruction and identification with the Run II D0 detector
  • 2014
  • Ingår i: Nuclear Instruments and Methods in Physics Research Section A : Accelerators, Spectrometers, Detectors and Associated Equipment. - 0168-9002 .- 1872-9576. ; 737, s. 281-294
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present an overview of the muon reconstruction and identification methods employed by the DO collaboration to analyze the Run II (2001-2011) p (p) over bar data of the Fermilab Tevatron collider at root s = 1.96 TeV. We discuss the performance of these methods, how it is measured using DO data, and how it is properly modeled by the DO simulation program. In its pseudorapidity acceptance, vertical bar eta vertical bar &lt; 2, the muon system identifies high-p(T) muons (p(T) greater than or similar to 10 GeV) with efficiencies ranging from 72% to 89%. Muons tracks are reconstructed in the DO central tracking system with efficiencies ranging from 85% to 92% and with a typical relative momentum resolution of 10% for p(T) = 40 GeV. Isolation criteria reject multijet background with efficiencies of 87-99%.</p>
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4.
  • Abazov, V. M., et al. (författare)
  • Bounds on an Anomalous Dijet Resonance in W plus jets Production in p(p)over-bar Collisions at root s=1.96 TeV
  • 2011
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 107:1, s. 011804
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present a study of the dijet invariant mass spectrum in events with two jets produced in association with a W boson in data corresponding to an integrated luminosity of 4.3 fb(-1) collected with the D0 detector at root s = 1.96 TeV. We find no evidence for anomalous resonant dijet production and derive upper limits on the production cross section of an anomalous dijet resonance recently reported by the CDF Collaboration, investigating the range of dijet invariant mass from 110 to 170 GeV/c(2). The probability of the D0 data being consistent with the presence of a dijet resonance with 4 pb production cross section at 145 GeV/c(2) is 8 x 10(-6).</p>
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5.
  • Abazov, V. M., et al. (författare)
  • Combination of D0 measurements of the top quark mass
  • 2017
  • Ingår i: Physical Review D : covering particles, fields, gravitation, and cosmology. - AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 95:11
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present a combination of measurements of the top quark mass by the D0 experiment in the lepton + jets and dilepton channels. We use all the data collected in Run I (1992-1996) at root s = 1.8 TeV and Run II (2001-2011) at root s = 1.96 TeV of the Tevatron p (p) over bar collider, corresponding to integrated luminosities of 0.1 fb(-1) and 9.7 fb(-1), respectively. The combined result is: m(t) = 174.95 +/- 0.40(stat)+/- 0.64(syst) GeV = 174.95 +/- 0.75 GeV.</p>
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6.
  • Abazov, V. M., et al. (författare)
  • Direct measurement of the mass difference between top and antitop quarks
  • 2011
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 84:5, s. 052005
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present a direct measurement of the mass difference between top and antitop quarks (Delta m) in lepton + jets t (t) over bar final states using the "matrix element" method. The purity of the lepton + jets sample is enhanced for t (t) over bar events by identifying at least one of the jets as originating from a b quark. The analyzed data correspond to 3.6 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV acquired by D0 in Run II of the Fermilab Tevatron Collider. The combination of the e + jets and mu + jets channels yields Delta m = 0.8 +/- 1.8(stat) +/- 0.5(syst) GeV, which is in agreement with the standard model expectation of no mass difference.</p>
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7.
  • Abazov, V. M., et al. (författare)
  • Forward-backward asymmetry in top quark-antiquark production
  • 2011
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 84:11, s. 112005
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present a measurement of forward-backward asymmetry in top quark-antiquark production in proton-antiproton collisions in the final state containing a lepton and at least four jets. Using a data set corresponding to an integrated luminosity of 5.4 fb(-1), collected by the D0 experiment at the Fermilab Tevatron Collider, we measure the t (t) over bar forward-backward asymmetry to be (9.2 +/- 3.7)% at the reconstruction level. When corrected for detector acceptance and resolution, the asymmetry is found to be (19.6 +/- 6.5)%. We also measure a corrected asymmetry based on the lepton from a top quark decay, found to be (15.2 +/- 4.0)%. The results are compared to predictions based on the next-to-leading-order QCD generator MC@NLO. The sensitivity of the measured and predicted asymmetries to the modeling of gluon radiation is discussed.</p>
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8.
  • Abazov, V. M., et al. (författare)
  • Improved determination of the width of the top quark
  • 2012
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 85:9, s. 091104
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present an improved determination of the total width of the top quark, Gamma(t), using 5.4 fb(-1) of integrated luminosity collected by the D0 Collaboration at the Tevatron p (p) over bar Collider. The total width Gamma(t) is extracted from the partial decay width Gamma(t -&gt; Wb) and the branching fraction B(t -&gt; Wb). Gamma(t -&gt; Wb) is obtained from the t-channel single top-quark production cross section and B(t -&gt; Wb) is measured in t (t) over bar events. For a top mass of 172.5 GeV, the resulting width is Gamma(t) = 2.00(-0.43)(+0.47) GeV. This translates to a top-quark lifetime of tau(t) = (3.29(-0.63)(+0.90)) x 10(-25) s. We also extract an improved direct limit on the Cabibbo-Kobayashi-Maskawa quark-mixing matrix element 0.81 &lt; vertical bar V-tb vertical bar &lt;= 1 at 95% C.L. and a limit of vertical bar V-tb'vertical bar &lt; 0.59 for a high-mass fourth-generation bottom quark assuming unitarity of the fourth-generation quark-mixing matrix.</p>
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9.
  • Abazov, V. M., et al. (författare)
  • Jet energy scale determination in the DO experiment
  • 2014
  • Ingår i: Nuclear Instruments and Methods in Physics Research Section A : Accelerators, Spectrometers, Detectors and Associated Equipment. - 0168-9002 .- 1872-9576. ; 763, s. 442-475
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The calibration of jet energy measured in the DO detector is presented, based on p (p) over bar collisions at a center-of-mass energy of 1.96 TeV at the Fermilab Tevatron collider, jet energies are measured using a sampling calorimeter composed of uranium and liquid argon as the passive and active media, respectively. This paper describes the energy calibration of jets performed with gamma+jet, Z+jet and dilet events, with jet transverse momentum p(T) &gt; 6 GeV and pseudorapidity range vertical bar eta vertical bar &lt; 3.6, The corrections are measured separately for data and simulation, achieving a precision of 1.4-1.8% for jets in the central part of the calorimeter ancl up to 3.5% for the jets with pseudorapidity vertical bar eta vertical bar = 3.0. Specific corrections are extracted to enhance the description of jet energy in simulation and in particular of the effects due to the flavor of the parton originating the jet, correcting biases up to 3-4% in jets with low PT originating from gluons and up to 6-8% in jets from b quarks. Published by Elsevier B.V.</p>
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10.
  • Abazov, V. M., et al. (författare)
  • Measurement of the anomalous like-sign dimuon charge asymmetry with 9 fb(-1) of p(p)over-bar collisions
  • 2011
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 84:5, s. 052007
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present an updated measurement of the anomalous like-sign dimuon charge asymmetry A(sl)(b) for semileptonic b-hadron decays in 9.0 fb(-1) of p (p) over bar collisions recorded with the D0 detector at a center-of-mass energy of root s = 1.96 TeV at the Fermilab Tevatron collider. We obtain A(sl)(b) = (-0.787 +/- 0.172(stat) +/- 0.093(syst)%. This result differs by 3.9 standard deviations from the prediction of the standard model and provides evidence for anomalously large CP violation in semileptonic neutral B decay. The dependence of the asymmetry on the muon impact parameter is consistent with the hypothesis that it originates from semileptonic b-hadron decays.</p>
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