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Cardiovascular Dise...
Cardiovascular Diseases And Psychiatric Disorders During The Diagnostic Workup Of Suspected Hematological Malignancy
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- Liu, Qianwei (author)
- Karolinska Institutet,Karolinska Institute
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- Andersson, Therese Ml (author)
- Karolinska Institutet,Karolinska Institute
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- Jöud, Anna (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad epidemiologi,Forskargrupper vid Lunds universitet,Miljöepidemiologi,Epidemiologi,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied epidemiology,Lund University Research Groups,Environmental Epidemiology,Epidemiology
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- Shen, Qing (author)
- Karolinska Institutet,Karolinska Institute
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- Schelin, Maria Ec (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tillämpad epidemiologi,Forskargrupper vid Lunds universitet,Palliativt Utvecklingscentrum,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Applied epidemiology,Lund University Research Groups,The Institute for Palliative Care,Skåne University Hospital
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- Magnusson, Patrik Ke (author)
- Karolinska Institutet,Karolinska Institute
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- Smedby, Karin E (author)
- Karolinska Institutet
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- Fang, Fang (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2019
- 2019
- English 10 s.
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In: Clinical Epidemiology. - 1179-1349. ; 11, s. 1025-1034
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Abstract
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- Background: Little attention has been given to the risk of cardiovascular and psychiatric comorbidities during the clinical evaluation of a suspected hematological malignancy.Methods: Based on Skåne Healthcare Register, we performed a population-based cohort study of 1,527,449 individuals residing during 2005-2014 in Skåne, Sweden. We calculated the incidence rate ratios (IRRs) of cardiovascular diseases or psychiatric disorders during the diagnostic workup of 5495 patients with hematological malignancy and 18,906 individuals that underwent a bone marrow aspiration or biopsy or lymph node biopsy without receiving a diagnosis of any malignancy ("biopsied individuals"), compared to individuals without such experience (i.e., reference).Results: There was a higher rate of cardiovascular diseases during the diagnostic workup of patients with hematological malignancy (overall IRR, 3.3; 95% CI, 2.9 to 3.8; greatest IRR for embolism and thrombosis, 8.1; 95% CI, 5.2 to 12.8) and biopsied individuals (overall IRR, 4.9; 95% CI, 4.6 to 5.3; greatest IRR for stroke, 37.5; 95% CI, 34.1 to 41.2), compared to reference. Similarly, there was a higher rate of psychiatric disorders during the diagnostic workup of patients with hematological malignancy (IRR, 2.1; 95% CI, 1.5 to 2.8) and biopsied individuals (IRR, 3.1; 95% CI, 2.9 to 3.4). The rate increases were greater around the time of diagnosis or biopsy, compared to thereafter, for both outcomes.Conclusion: There were higher rates of cardiovascular diseases and psychiatric disorders during the diagnostic workup of a suspected hematological malignancy, regardless of the final diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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