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Sökning: WFRF:(Smirnova Daria)

  • Resultat 1-5 av 5
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1.
  • Fountoulakis, Konstantinos N., et al. (författare)
  • Gender, age at onset, and duration of being ill as predictors for the long-term course and outcome of schizophrenia : an international multicenter study
  • 2022
  • Ingår i: CNS Spectrums. - : CAMBRIDGE UNIV PRESS. - 1092-8529 .- 2165-6509. ; 27:6, s. 716-723
  • Tidskriftsartikel (refereegranskat)abstract
    • Background The aim of the current study was to explore the effect of gender, age at onset, and duration on the long-term course of schizophrenia. Methods Twenty-nine centers from 25 countries representing all continents participated in the study that included 2358 patients aged 37.21 +/- 11.87 years with a DSM-IV or DSM-5 diagnosis of schizophrenia; the Positive and Negative Syndrome Scale as well as relevant clinicodemographic data were gathered. Analysis of variance and analysis of covariance were used, and the methodology corrected for the presence of potentially confounding effects. Results There was a 3-year later age at onset for females (P < .001) and lower rates of negative symptoms (P < .01) and higher depression/anxiety measures (P < .05) at some stages. The age at onset manifested a distribution with a single peak for both genders with a tendency of patients with younger onset having slower advancement through illness stages (P = .001). No significant effects were found concerning duration of illness. Discussion Our results confirmed a later onset and a possibly more benign course and outcome in females. Age at onset manifested a single peak in both genders, and surprisingly, earlier onset was related to a slower progression of the illness. No effect of duration has been detected. These results are partially in accord with the literature, but they also differ as a consequence of the different starting point of our methodology (a novel staging model), which in our opinion precluded the impact of confounding effects. Future research should focus on the therapeutic policy and implications of these results in more representative samples.
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2.
  • Fountoulakis, Konstantinos N., et al. (författare)
  • Staging of Schizophrenia With the Use of PANSS : An International Multi-Center Study
  • 2019
  • Ingår i: International Journal of Neuropsychopharmacology. - : Oxford University Press. - 1461-1457 .- 1469-5111. ; 22:11, s. 681-697
  • Tidskriftsartikel (refereegranskat)abstract
    • IntroductionA specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.MethodsTwenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.ResultsExploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.DiscussionThis study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.
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3.
  • Gao, Jun, et al. (författare)
  • Observation of Anderson phase in a topological photonic circuit
  • 2022
  • Ingår i: Physical Review Research. - : American Physical Society (APS). - 2643-1564. ; 4:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Disordered systems play a central role in condensed matter physics, quantum transport, and topological photonics. It is commonly believed that a topological nontrivial phase would turn into a trivial phase where the transport vanishes under the effect of Anderson localization. Recent studies predict a counterintuitive result, that adding disorder to the trivial band structure triggers the emergence of protected edge states, the so-called topological Anderson phase. Here, we experimentally observe such a topological Anderson phase in a CMOS-compatible nanophotonic circuit, which implements the Su-Schrieffer-Heeger (SSH) model with incommensurate disorder in the intercell coupling amplitudes. The existence of the Anderson phase is verified by the spectral method, based on the continuous detection of the nanoscale light dynamics at the edge. Our results demonstrate the inverse transition between distinct topological phases in the presence of disorder, as well as offering a single-shot measurement technique to study the light dynamics in nanophotonic systems.
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4.
  • Smirnova, Daria, et al. (författare)
  • Atomistic description of self-diffusion in molybdenum: A comparative theoretical study of non-Arrhenius behavior
  • 2020
  • Ingår i: Physical Review Materials. - : AMER PHYSICAL SOC. - 2475-9953. ; 4:1
  • Tidskriftsartikel (refereegranskat)abstract
    • According to experimental observations, the temperature dependence of self-diffusion coefficient in most body-centered cubic metals (bcc) exhibits non-Arrhenius behavior. The origin of this behavior is likely related to anharmonic vibrational effects at elevated temperatures. However, it is still debated whether anharmonicity affects more the formation or migration of monovacancies, which are known to govern the self-diffusion. In this extensive atomistic simulation study we investigated thermodynamic properties of monovacancies in bcc molybdenum, here taken as a representative model system, from zero temperature to the melting point. We combined first-principles calculations and classical simulations based on three widely used interatomic potentials for Mo. In our analysis we employ static and dynamic atomistic calculations as well as statistical sampling techniques and thermodynamic integration to achieve thorough information about temperature variations of vacancy formation and migration free energies and diffusivities. In addition, we carry out large-scale molecular dynamics simulations that enable direct observation of high-temperature self-diffusion at the atomic scale. By scrutinizing the results obtained by different models and methods, we conclude that the peculiar self-diffusion behavior is likely caused by strong temperature dependence of the vacancy formation energy.
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5.
  • Aad, G., et al. (författare)
  • 2014
  • Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :11
  • Tidskriftsartikel (refereegranskat)
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  • Resultat 1-5 av 5

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