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- Bergdahl, Lovisa, 1971-
(author)
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Seeing Otherwise : Renegotiating Religion and Democracy as Questions for Education
- 2010
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Doctoral thesis (other academic/artistic)abstract
- Rooted in philosophy of education, the overall purpose of this dissertation is to renegotiate the relationship between education, religion, and democracy by placing the religious subject at the centre of this renegotiation. While education is the main focus, the study draws its energy from the fact that tensions around religious beliefs and practices seem to touch upon the very heart of liberal democracy. The study reads the tensions religious pluralism seems to be causing in contemporary education through a post-structural approach to difference and subjectivity. The purpose is accomplished in three movements. The first aims to show why the renegotiation is needed by examining how the relationship between education, democracy, and religion is currently being addressed in cosmopolitan education and deliberative education. The second movement introduces a model of democracy, radical democracy, that sees the process of defining the subject as a political process. It is argued that this model offers possibilities for seeing religion and the religious subject as part of the struggle for democracy. The third movement aims to develop how the relationship between education, democracy, and religion might change if we bring them together in a conversation whose conditions are not ‘owned’ by any one of them. To create this conversation, Hannah Arendt, Jacques Derrida, Søren Kierkegaard, and Emmanuel Levinas are brought together around three themes – love, freedom, and dialogue – referred to as ‘windows.’ The windows offer three examples in which religious subjectivity is made manifest but they also create a shift in perspective that invites other ways of seeing the tensions between religion and democracy. The aim of the study is to discuss how education might change when religion and democracy become questions for it through the perspectives offered in the windows and what this implies for the particular religious subject.
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| 2. |
- Brabie, Dan, 1975-
(author)
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On Derailment-Worthiness in Rail Vehicle Design : Analysis of vehicle features influencing derailment processes and consequences
- 2007
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Doctoral thesis (other academic/artistic)abstract
- This thesis aims at systematically studying the possibilities of minimizing devastating consequences of high-speed rail vehicle derailments by appropriate measures and features in the train design including the running gear. Firstly, an empirical database is established containing as much relevant information as possible of past incidents and accidents that have occurred at substantial running speeds due to mechanical failure close to the interface between the running gear and the track. Other causes that ultimately brought the train in a derailed condition are also covered. Although various accidental circumstances make each derailment a unique event, certain patterns appear to emerge which lead to several critical vehicle parameters capable of influencing the outcome of a derailment or preventing a derailment to occur. Secondly, the possibility of preventing wheel climbing derailments after an axle journal failure is studied by implementing mechanical restrictions between wheelsets and bogie frame. In this respect, a multi body system (MBS) computer model is developed to account for such an axle failure condition, which is successfully validated on the basis of two authentic passenger car events. In order to study the overall post-derailment vehicle behaviour, in particular the wheelsets’ vertical motion and lateral deviation on sleepers, a comprehensive MBS post-derailment module is developed and implemented in the commercially available software GENSYS. The model detects wheel-sleeper impact conditions and applies valid force resultants calculated through linear interpolation based on a pre-defined look-up table. The table was constructed through exhaustive finite element (FE) wheel to concrete sleeper impact simulations utilising the commercially available software LS-DYNA. The MBS post-derailment module has been validated successfully in several stages, including a correct prediction of the derailing wheelset’s trajectory over ten consecutive sleepers in comparison with an authentic passenger vehicle derailment event. An extensive simulation analysis on the feasibility of utilizing alternative substitute guidance mechanisms attached to the running gear on rail vehicles is presented, as means of minimizing the lateral deviation. Three low-reaching guidance mechanisms attached onto the running gear (bogie frame, brake disc and axle journal box) are analysed in terms of geometrical parameters for a successful engagement with the rail in order to prevent large lateral deviations after twelve different derailment scenarios. Three conventional coupled passenger trailing cars are investigated in terms of lateral deviation and vehicle overturning tendency after derailments on tangent and curved track. This is performed as a function of various vehicle design features and parameters such as: maximum centre coupler yaw angle, carbody height of centre of gravity, coupler height and additional running gear features. In a similar manner, the articulated train concept is investigated in terms of the post-derailment vehicle behaviour as a function of different inter-carbody damper characteristics and running gear features.
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| 3. |
- Kunz, Sabine, 1981-
(author)
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Sugar-modulated gene expression and cell division in cell culture and seedlings of A. thaliana
- 2014
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Doctoral thesis (other academic/artistic)abstract
- Throughout their life cycle, plants adjust growth in response to their developmental and environmental situation within the limits of their energetic capacities. This capacity is defined by the local sugar availability, which is constantly modulated through synthesis, transport and consumption of sugar. The monitoring of sugar presence is carried out by a complex signalling network in which simple sugars (e.g. glucose, fructose and sucrose) act as metabolic signals for the modulation of physiological processes. However, often it remains unclear whether the regulation is induced by the simple sugars themselves or by their derivatives generated during sugar metabolism. This thesis focuses on the dissection of distinct sugar signals, their generation, perception and impact on the modulation of gene expression and cell division both in cell culture and young seedlings.Based on a stem-cell-like A. thaliana cell culture, which could be sustained in a hormone-free media, a new biological system, supplied with Xyl as the only carbon source was developed. The performance of a variety of sugar and sugar analogue treatments in this novel system allowed for the identification of sugar-responsive candidate genes, which were specifically regulated by glucose, fructose and sucrose. For several genes (e.g. bZIP63, AT5g22920, TPS9, MGD2 and BT2), this regulation required both sugar transport into the cytosol and metabolisation for the generation of the signal. Furthermore, gene expression analyses in young A. thaliana seedlings indicated the requirement for the catalytic activity of hexokinase 1 in the regulation of bZIP63, Atg22920 and BT2 under conditions of a perturbed carbohydrate balance. These findings have been combined in a proposed model for the transcriptional regulation of bZIP63, AT5g22920, TPS9, MGD2 and BT2, which further proposes a function of those genes in the regulation of cell division.The optimisation of a protocol for long-term real-time live-cell imaging provided a valuable tool to show that, similar to gene expression, the progression of cell division depended on a sugar-type-specific regulation at the single-cell level; this regulation was most likely caused by prolongation of the interphase. Together with the observation of cell death and growth arrest of the primary root in intact seedlings in response to the glucose analogue 2dog, this led to the conclusion that sugar signals themselves were sufficient to induce cell division. However, the continuation of cell cycle progression and consequently organ growth over long-time required the availability of the energy contained in the sugar.
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| 4. |
- Lundahl, Anna, 1980-
(author)
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In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites
- 2010
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Doctoral thesis (other academic/artistic)abstract
- The general aim of this thesis was to improve the understanding of the in vivo pharmacokinetics and, in particular, the metabolism of finasteride, a 5α-reductase inhibitor used in the treatment of enlarged prostate glands and male pattern baldness. CYP3A4 has been identified as the major enzyme involved in the sequential metabolism of finasteride to ω-OH finasteride (M1) and ω-COOH finasteride (M3). The consequences of induced and inhibited metabolism on the pharmacokinetics of finasteride and its metabolites were investigated in humans and pigs. Both studies included bile collection. The collected human and pig samples were used for the metabolite identification. As expected, induced metabolism led to reduced plasma exposure of finasteride and inhibited metabolism had the opposite effect. The interactions were investigated in detail and included examination of the biliary pharmacokinetics of finasteride and its metabolites. In pigs, the study included monitoring of the hepatic extraction over time, deconvolution and the development of a semi-physiological model for comparison of the effects on the gut wall and liver metabolism. For M3, the concentration ratios of bile to plasma and the renal clearance indicated that carrier-mediated processes are involved in the biliary and urinary excretion. This was not, however, the case for finasteride. The metabolite, M1, could not be quantified either in humans or pigs. Instead, two other OH metabolites, M1 isomers, were identified in humans. These metabolites were found to undergo glucuronide conjugation. In humans, one glucuronide was identified intact and in pigs, both glucuronides were identified intact in bile and in urine. In addition, a glucuronide of M3 was identified in human bile. In conclusion, advances have been made in the understanding of the pharmacokinetics of finasteride, in particular in relation to the metabolism. Hopefully, the findings of this comprehensive investigation can be applied to other drugs and novel chemical entities.
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| 5. |
- Stavlöt, Ulrika, 1969-
(author)
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Essays on Culture and Trade
- 2005
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Doctoral thesis (other academic/artistic)abstract
- This thesis consists of three self-contained essays. The first two essays address the consumption of culture and are closely related in terms of the theoretical framework used. The third essay is a separate analysis of international trade and competition.The studies of culture are motivated by the special treatment of culture consumption in most modern societies: there are usually large, government-provided subsidies, the aim of which is to stimulate both the production and the consumption of culture. The purpose of the present work is to explore reasons for this special treatment. Using a stylized theoretical framework, the essays contrast culture with another, generic, good or activity. Culture is thus regarded as an "experience good": previous consumption of the good enhances the current appreciation of the good. The generic good is one where experience is assumed not to be at all relevant for the appreciation of the good. For experience goods, decisions made today will influence future utility and future choices. This makes the intertemporal preferences essential. If, in particular, consumers have time-inconsistent preferences of the type that can be characterized as a present-bias---modeled with "multiple selves" using quasi-geometric discounting---as opposed to standard, time-consistent preferences, there will be a case for government subsidies. The first essay explores this possibility in detail in a framework where experience is mainly of importance in the short run. The second essay then studies cases where experience is more potent and can cause persistent diversity in culture consumption across individuals."Culture and Control: Should There Be Large Subsidies to Culture?" studies the circumstances under which public support for culture is warranted. A policy example is designed to illustrate important aspects of public support systems currently in place, and is calibrated to Swedish data. The essay concludes that, given present-biased agents with self-control problems, public support of culture can work as a commitment device and improve long-run welfare. Furthermore, it is demonstrated that welfare-maximizing subsidies to culture can be substantial if the present-bias is profound and the taste-cultivation property of culture consumption is pronounced."Origins of the Diversity of Culture Consumption" analyzes the diversity of culture consumption among individuals. If the culture good and the generic good are sufficiently close substitutes in a static sense, very large and persistent differences in the consumption of highbrow culture across consumers can be explained by differences in initial experience levels alone. Moreover, slight differences in preferences and time endowments can cause significant diversity between individuals, both in the long- and short-run levels of culture consumption. In addition, if consumers have time-inconsistent preferences, further diversity can be rationalized. If there is a present-bias, there may also be Pareto-ranked multiple equilibria with "optimism" and "pessimism": high (low) culture consumption of the current self is rationalized, based on the belief that future culture consumption will be high (low)."Has international competition increased? Estimates of residual demand elasticities in export markets" studies the impact of the last decades of intense economic integration on the competitive conduct of Swedish export industries. The functional relationship between the inverted residual demand elasticity and the Lerner index is used to estimate markups in eight industries. The econometric evidence suggests a deviation from competitive behavior in all industries. Moreover, the results demonstrate a trend of decreasing market power.
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