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A GWAS on Helicobac...
A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk
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- Berthenet, Elvire (författare)
- Swansea University, United Kingdom
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- Yahara, Koji (författare)
- National Institute of Infectious Diseases, Toyama, Japan
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- Thorell, Kaisa (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Pascoe, Ben (författare)
- University of Bath, United Kingdom
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- Meric, Guillaume (författare)
- University of Bath, United Kingdom
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- Mikhail, Jane M. (författare)
- Swansea University, United Kingdom / Cardiff University, United Kingdom
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- Engstrand, Lars (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Enroth, Helena (författare)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Infektionsbiologi, Infection Biology
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- Burette, Alain (författare)
- Centre Hospitalier Interrégional Edith Cavell/Site de la Basilique, Brussels, Belgium
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- Megraud, Francis (författare)
- Centre National de Référence des Campylobacters et des Hélicobacters, Bordeaux, France / University Bordeaux, France
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- Varon, Christine (författare)
- University Bordeaux, France
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- Atherton, John C. (författare)
- Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom
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- Smith, Sinead (författare)
- Trinity College Dublin, Ireland,Swansea University Medical School, Swansea University, Microbiology and Infectious Disease Group, Swansea, United Kingdom
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- Wilkinson, Thomas S. (författare)
- Swansea University Medical School, Swansea University, Microbiology and Infectious Disease Group, Swansea, United Kingdom
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- Hitchings, Matthew D. (författare)
- Swansea University, United Kingdom
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- Falush, Daniel (författare)
- University of Bath, United Kingdom
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- Sheppard, Samuel K. (författare)
- University of Bath, United Kingdom
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(creator_code:org_t)
- 2018-08-02
- 2018
- Engelska.
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Ingår i: BMC Biology. - : BioMed Central. - 1741-7007. ; 16:1
- Relaterad länk:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://bmcbiol.biom...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND:Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gastric cancer. Epidemiological evidence shows that progression to cancer depends upon the host and pathogen factors, but questions remain about why cancer phenotypes develop in a minority of infected people. Here, we use comparative genomics approaches to understand how genetic variation amongst bacterial strains influences disease progression.RESULTS:We performed a genome-wide association study (GWAS) on 173 H. pylori isolates from the European population (hpEurope) with known disease aetiology, including 49 from individuals with gastric cancer. We identified SNPs and genes that differed in frequency between isolates from patients with gastric cancer and those with gastritis. The gastric cancer phenotype was associated with the presence of babA and genes in the cag pathogenicity island, one of the major virulence determinants of H. pylori, as well as non-synonymous variations in several less well-studied genes. We devised a simple risk score based on the risk level of associated elements present, which has the potential to identify strains that are likely to cause cancer but will require refinement and validation.CONCLUSION:There are a number of challenges to applying GWAS to bacterial infections, including the difficulty of obtaining matched controls, multiple strain colonization and the possibility that causative strains may not be present when disease is detected. Our results demonstrate that bacterial factors have a sufficiently strong influence on disease progression that even a small-scale GWAS can identify them. Therefore, H. pylori GWAS can elucidate mechanistic pathways to disease and guide clinical treatment options, including for asymptomatic carriers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- GWAS
- Gastric cancer
- Helicobacter pylori
- INF502 Biomarkörer
- INF502 Biomarkers
- Infection Biology
- Infektionsbiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Berthenet, Elvir ...
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Yahara, Koji
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Thorell, Kaisa
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Pascoe, Ben
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Meric, Guillaume
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Mikhail, Jane M.
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visa fler...
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Engstrand, Lars
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Enroth, Helena
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Burette, Alain
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Megraud, Francis
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Varon, Christine
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Atherton, John C ...
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Smith, Sinead
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Wilkinson, Thoma ...
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Hitchings, Matth ...
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Falush, Daniel
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Sheppard, Samuel ...
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