| 1. |
- Ikram, M. Arfan, et al.
(författare)
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Common variants at 6q22 and 17q21 are associated with intracranial volume
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 539-544
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Tidskriftsartikel (refereegranskat)abstract
- During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
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| 2. |
- Taal, H. Rob, et al.
(författare)
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Common variants at 12q15 and 12q24 are associated with infant head circumference
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 532-538
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Tidskriftsartikel (refereegranskat)abstract
- To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
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| 3. |
- Laurent, C Matthew, et al.
(författare)
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A Practical Approach to Monitoring Recovery: Development of a Perceived Recovery Status Scale
- 2011
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Ingår i: Journal of Strength and Conditioning Research. - 1064-8011 .- 1533-4287. ; 25:3, s. 620-628
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Tidskriftsartikel (refereegranskat)abstract
- A practical approach to monitoring recovery: development of a perceived recovery status scale. J Strength Cond Res 24(x): 000-000, 2010-The aim of this study was to develop and test the practical utility of a perceived recovery status (PRS) scale. Sixteen volunteers (8 men, 8 women) performed 4 bouts of high-intensity intermittent sprint exercise. After completion of the baseline trial, in a repeated-measures design, subjects were given variable counterbalanced recovery periods of 24, 48, and 72 hours whereupon they repeated an identical intermittent exercise protocol. After a warm-up period, but before beginning each subsequent bout of intermittent sprinting, each individual provided their perceived level of recovery with a newly developed PRS scale. Similar to perceived exertion during exercise, PRS was based on subjective feelings. The utility of the PRS scale was assessed by measuring the level of agreement of an individual's perceived recovery relative to their performance during the exercise bout. Perceived recovery status and change (both positive and negative) in sprint performance during multiple bouts of repeated sprint exercise were moderately negative correlated (r = -0.63). Additionally, subjects were able to accurately assess level of recovery using the PRS scale indicated by correspondence with negative and positive changes in total sprint time relative to their previous session. The ability to detect changes in performance using a noninvasive psychobiological tool to identify differences in performance was independent of other psychological and physiological markers measured during testing, because there were no differences (p > 0.05) among ratings of perceived exertion (RPE), heart rate, blood lactate concentration, or session RPE values among any of the performance trials. Although further study is needed, current results indicate a subjective approach may be an effective means for assessing recovery from day to day, at least under similar conditions.
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| 4. |
- Sjökvist, Jesper, et al.
(författare)
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Recovery from high-intensity training sessions in female soccer players
- 2011
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Ingår i: Journal of Strength and Conditioning Research. - 1064-8011 .- 1533-4287. ; 25:6, s. 1726-1735
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Tidskriftsartikel (refereegranskat)abstract
- This study quantified the performance recovery time requirements after training sessions using high-intensity soccer drills with and without the ball in National Collegiate Athletic Association Division I female soccer players. Recovery time periods (24, 48, 72 hours of rest) from high-intensity soccer training sessions using drills with and without the ball were evaluated. Markers of recovery were each individual's performance relative to baseline performance in countermovement jump (CMJ) height, 5 bound jumps for distance (5BT), 20-m sprint (20SP), session rating of perceived effort (S-RPE), and heart rate (HR). Repeated-measures analysis of variance revealed a significant difference in CMJ performance (p < 0.04) and S-RPE (p < 0.02) after 24 hours of rest but not at 48 or 72 hours compared to baseline. There were no significant differences in 20SP, 5BT, or HR after 24, 48, or 72-hour recovery (p > 0.05). Therefore, high-intensity training drills produced a sufficient conditioning stimulus with little chance of underrecovery for the performance measures we tested. Countermovement jump and S-RPE may be more sensitive performance recovery indicators.
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