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Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Ellinor, Patrick T. (author)
Lunetta, Kathryn L. (author)
Albert, Christine M. (author)
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Glazer, Nicole L. (author)
Ritchie, Marylyn D. (author)
Smith, Albert V. (author)
Arking, Dan E. (author)
Mueller-Nurasyid, Martina (author)
Krijthe, Bouwe P. (author)
Lubitz, Steven A. (author)
Bis, Joshua C. (author)
Chung, Mina K. (author)
Doerr, Marcus (author)
Ozaki, Kouichi (author)
Roberts, Jason D. (author)
Smith, Gustav (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Pfeufer, Arne (author)
Sinner, Moritz F. (author)
Lohman, Kurt (author)
Ding, Jingzhong (author)
Smith, Nicholas L. (author)
Smith, Jonathan D. (author)
Rienstra, Michiel (author)
Rice, Kenneth M. (author)
Van Wagoner, David R. (author)
Magnani, Jared W. (author)
Wakili, Reza (author)
Clauss, Sebastian (author)
Rotter, Jerome I. (author)
Steinbeck, Gerhard (author)
Launer, Lenore J. (author)
Davies, Robert W. (author)
Borkovich, Matthew (author)
Harris, Tamara B. (author)
Lin, Honghuang (author)
Voelker, Uwe (author)
Voelzke, Henry (author)
Milan, David J. (author)
Hofman, Albert (author)
Boerwinkle, Eric (author)
Chen, Lin Y. (author)
Soliman, Elsayed Z. (author)
Voight, Benjamin F. (author)
Li, Guo (author)
Chakravarti, Aravinda (author)
Kubo, Michiaki (author)
Tedrow, Usha B. (author)
Rose, Lynda M. (author)
Ridker, Paul M. (author)
Conen, David (author)
Tsunoda, Tatsuhiko (author)
Furukawa, Tetsushi (author)
Sotoodehnia, Nona (author)
Xu, Siyan (author)
Kamatani, Naoyuki (author)
Levy, Daniel (author)
Nakamura, Yusuke (author)
Parvez, Babar (author)
Mahida, Saagar (author)
Furie, Karen L. (author)
Rosand, Jonathan (author)
Muhammad, Raafia (author)
Psaty, Bruce M. (author)
Meitinger, Thomas (author)
Perz, Siegfried (author)
Wichmann, H-Erich (author)
Witteman, Jacqueline C. M. (author)
Kao, W. H. Linda (author)
Kathiresan, Sekar (author)
Roden, Dan M. (author)
Uitterlinden, Andre G. (author)
Rivadeneira, Fernando (author)
McKnight, Barbara (author)
Sjögren, Marketa (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Newman, Anne B. (author)
Liu, Yongmei (author)
Gollob, Michael H. (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Tanaka, Toshihiro (author)
Stricker, Bruno H. Ch (author)
Felix, Stephan B. (author)
Alonso, Alvaro (author)
Darbar, Dawood (author)
Barnard, John (author)
Chasman, Daniel I. (author)
Heckbert, Susan R. (author)
Benjamin, Emelia J. (author)
Gudnason, Vilmundur (author)
Kaeaeb, Stefan (author)
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 (creator_code:org_t)
2012-04-29
2012
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:6, s. 88-670
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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art (subject category)
ref (subject category)

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By the author/editor
Ellinor, Patrick ...
Lunetta, Kathryn ...
Albert, Christin ...
Glazer, Nicole L ...
Ritchie, Marylyn ...
Smith, Albert V.
show more...
Arking, Dan E.
Mueller-Nurasyid ...
Krijthe, Bouwe P ...
Lubitz, Steven A ...
Bis, Joshua C.
Chung, Mina K.
Doerr, Marcus
Ozaki, Kouichi
Roberts, Jason D ...
Smith, Gustav
Pfeufer, Arne
Sinner, Moritz F ...
Lohman, Kurt
Ding, Jingzhong
Smith, Nicholas ...
Smith, Jonathan ...
Rienstra, Michie ...
Rice, Kenneth M.
Van Wagoner, Dav ...
Magnani, Jared W ...
Wakili, Reza
Clauss, Sebastia ...
Rotter, Jerome I ...
Steinbeck, Gerha ...
Launer, Lenore J ...
Davies, Robert W ...
Borkovich, Matth ...
Harris, Tamara B ...
Lin, Honghuang
Voelker, Uwe
Voelzke, Henry
Milan, David J.
Hofman, Albert
Boerwinkle, Eric
Chen, Lin Y.
Soliman, Elsayed ...
Voight, Benjamin ...
Li, Guo
Chakravarti, Ara ...
Kubo, Michiaki
Tedrow, Usha B.
Rose, Lynda M.
Ridker, Paul M.
Conen, David
Tsunoda, Tatsuhi ...
Furukawa, Tetsus ...
Sotoodehnia, Non ...
Xu, Siyan
Kamatani, Naoyuk ...
Levy, Daniel
Nakamura, Yusuke
Parvez, Babar
Mahida, Saagar
Furie, Karen L.
Rosand, Jonathan
Muhammad, Raafia
Psaty, Bruce M.
Meitinger, Thoma ...
Perz, Siegfried
Wichmann, H-Eric ...
Witteman, Jacque ...
Kao, W. H. Linda
Kathiresan, Seka ...
Roden, Dan M.
Uitterlinden, An ...
Rivadeneira, Fer ...
McKnight, Barbar ...
Sjögren, Marketa
Newman, Anne B.
Liu, Yongmei
Gollob, Michael ...
Melander, Olle
Tanaka, Toshihir ...
Stricker, Bruno ...
Felix, Stephan B ...
Alonso, Alvaro
Darbar, Dawood
Barnard, John
Chasman, Daniel ...
Heckbert, Susan ...
Benjamin, Emelia ...
Gudnason, Vilmun ...
Kaeaeb, Stefan
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
Articles in the publication
Nature Genetics
By the university
Lund University

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