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Healthy lifestyle and the risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition study

Naudin, Sabine (author)
International Agency for Research on Cancer, World Health Organization
Margalef, Marta Solans (author)
University of Girona
Hosnijeh, Fatemeh Saberi (author)
Utrecht University
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Nieters, Alexandra (author)
Albert-Ludwigs University Freiburg
Kyrø, Cecilie (author)
Danish Cancer Society
Tjønneland, Anne (author)
Danish Cancer Society
Dahm, Christina C. (author)
Aarhus University
Overvad, Kim (author)
Aarhus University,Aalborg University Hospital
Mahamat-Saleh, Yahya (author)
Centre for Research in Epidemiology and Population Health (CESP)
Besson, Caroline (author)
Centre Hospitalier de Versailles,Centre for Research in Epidemiology and Population Health (CESP)
Boutron-Ruault, Marie-Christine (author)
Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
Kühn, Tilman (author)
German Cancer Research Centre
Canzian, Federico (author)
German Cancer Research Centre
Schulze, Matthias B. (author)
University of Potsdam,German Institute of Human Nutrition
Peppa, Eleni (author)
Hellenic Health Foundation, Athens
Karakatsani, Anna (author)
National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
Trichopoulou, Antonia (author)
Hellenic Health Foundation, Athens
Sieri, Sabina (author)
Istituto Nazionale dei Tumori
Masala, Giovana (author)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
Panico, Salvatore (author)
University of Naples Federico II
Tumino, Rosario (author)
Civic and M.P Arezzo Hospital
Ricceri, Fulvio (author)
University of Turin
Chen, Sairah L. F. (author)
UiT The Arctic University of Norway, Tromsø
Barroso, Leila L. (author)
Catalan Institute of Oncology
Huerta, José M. (author)
Murcia Regional Health Council
Sánchez, Maria-Jose (author)
University of Granada,Andalusian School Of Public Health (EASP)
Ardanaz, Eva (author)
Health Research Institute of Navarra (IDISNA)
Menendez, Virginia (author)
Public Health Directorate
Exezarreta, Pilar Amiano (author)
Biodonostia Health Research Institute
Späth, Florentin, 1980- (author)
Umeå University,Umeå universitet,Onkologi
Jerkeman, Mats (author)
Lund University,Lunds universitet,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
Jirstrom, Karin (author)
Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Schmidt, Julie A. (author)
University of Oxford
Aune, Dagfinn (author)
Imperial College London,Bjørknes University College,Oslo university hospital
Weiderpass, Elisabete (author)
International Agency for Research on Cancer, World Health Organization
Riboli, Elio (author)
Imperial College London
Vermeulen, Roel (author)
Utrecht University
Casabonne, Delphine (author)
Catalan Institute of Oncology,Bellvitge University Hospital-IDIBELL
Gunter, Marc (author)
International Agency for Research on Cancer, World Health Organization
Brennan, Paul (author)
International Agency for Research on Cancer, World Health Organization
Ferrari, Pietro (author)
International Agency for Research on Cancer, World Health Organization
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 (creator_code:org_t)
2020-03-30
2020
English.
In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 147:6, s. 1649-1656
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Limited evidence exists on the role of modifiable lifestyle factors on the risk of lymphoma. In this rk, the associations between adherence to healthy lifestyles and risks of Hodgkin lymphoma (HL) and n-Hodgkin lymphoma (NHL) were evaluated in a large-scale European prospective cohort. Within the ropean Prospective Investigation into Cancer and Nutrition (EPIC), 2,999 incident lymphoma cases 32 HL and 2,746 NHL) were diagnosed among 453,808 participants after 15 years (median) of follow- . The healthy lifestyle index (HLI) score combined information on smoking, alcohol intake, diet, ysical activity and BMI, with large values of HLI expressing adherence to healthy behavior. Cox oportional hazards models were used to estimate lymphoma hazard ratios (HR) and 95% confidence terval (CI). Sensitivity analyses were conducted by excluding, in turn, each lifestyle factor from the HLI ore. The HLI was inversely associated with HL, with HR for a 1-standard deviation (SD) increment in the ore equal to 0.78 (95% CI: 0.66, 0.94). Sensitivity analyses showed that the association was mainly iven by smoking and marginally by diet. NHL risk was not associated with the HLI, with HRs for a 1-SD crement equal to 0.99 (0.95, 1.03), with no evidence for heterogeneity in the association across NHL btypes. In the EPIC study, adherence to healthy lifestyles was not associated with overall lymphoma or NHL risk, while an inverse association was observed for HL, although this was largely attributable to smoking. These findings suggest a limited role of lifestyle factors in the etiology of lymphoma subtypes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Keyword

Hodgkin lymphoma
non-Hodgkin lymphoma
healthy lifestyle index
EPIC
prospective study
EPIC
healthy lifestyle index
Hodgkin lymphoma
non-Hodgkin lymphoma
prospective study

Publication and Content Type

ref (subject category)
art (subject category)

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