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Outcomes associated...
Outcomes associated to serum phosphate levels in patients with suspected acute coronary syndrome
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- Xu, Hong (författare)
- Karolinska Institutet
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- Evans, Marie (författare)
- Karolinska Institutet
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- Gasparini, Alessandro (författare)
- Karolinska Institutet
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- Szummer, Karolina (författare)
- Karolinska Institutet
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- Spaak, Jonas (författare)
- Karolinska Institutet
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- Ärnlöv, Johan, 1970- (författare)
- Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lindholm, Bengt (författare)
- Karolinska Institutet
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- Jernberg, Tomas (författare)
- Karolinska Institutet
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- Carrero, Juan Jesús (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 32
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: We investigated the association between phosphate and the risk of adverse clinical outcomes in patients with manifest cardiovascular disease (CVD).METHODS: Observational study of patients hospitalized during 2006-2011 in Stockholm, Sweden, because of suspected acute coronary syndrome (ACS). The exposure was serum phosphate during the hospitalization. We modeled the association between phosphate and in-hospital death or in-hospital events (composite of myocardial infarction, cardiogenic shock, resuscitated cardiac arrest, atrial fibrillation, or atrioventricular block) as well as the one-year post-discharge risk of death or cardiovascular event (composite of myocardial re-infarction, heart failure and stroke). Confounders included demographics, comorbidities, kidney function, diagnoses, in-hospital procedures and therapies.RESULTS: Included were 2547 patients (68% men, mean age 67±14years) with median phosphate of 1.10 (range 0.14-4.20) mmol/L. During hospitalization, 198 patients died and 328 suffered an adverse event. Within one year post-discharge, further 381 deaths and 632 CVD events occurred. The associations of phosphate with mortality and CVD were J-shaped, with highest risk magnitudes at higher phosphate levels. For instance, compared to patients in the 50th percentile of phosphate distribution, those above the 75th percentile (1.3mmol/L, normal range) had significantly higher odds for in-hospital death [odds ratio 1.36, 95% confidence interval (CI) (1.08-1.71)] and of CVD post-discharge [sub-hazard ratios 1.17 (1.03-1.33)].CONCLUSIONS: In patients with suspected ACS, both higher and lower phosphate levels associated with increased risk of adverse outcomes during the index hospitalization and within one year post-discharge. The risk association was present already within normal-range serum phosphate values.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Acute coronary syndrome
- Chronic kidney disease
- Death
- in hospital
- Phosphate
- Post-discharge
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Xu, Hong
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Evans, Marie
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Gasparini, Aless ...
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Szummer, Karolin ...
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Spaak, Jonas
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Ärnlöv, Johan, 1 ...
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visa fler...
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Lindholm, Bengt
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Jernberg, Tomas
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Carrero, Juan Je ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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International Jo ...
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NEPHROLOGY DIALY ...
- Av lärosätet
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Högskolan Dalarna
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Uppsala universitet
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Karolinska Institutet